308796-09-0 Usage
Uses
Used in Organic Synthesis:
1-Ethylpropylzinc bromide is used as a reagent for the synthesis of various organic compounds, leveraging its ability to react with a wide range of electrophiles. This makes it instrumental in the creation of new carbon-carbon and carbon-heteroatom bonds, which are fundamental to the development of novel organic molecules.
Used in Pharmaceutical Industry:
In the pharmaceutical sector, 1-ethylpropylzinc bromide is utilized for the preparation of complex natural products and pharmaceuticals. Its versatility in forming necessary chemical bonds under various conditions is crucial for the synthesis of new drug candidates and the improvement of existing medications.
Used in the Preparation of Complex Natural Products:
1-Ethylpropylzinc bromide is employed as a key component in the synthesis of complex natural products. Its compatibility with a variety of reaction conditions allows for the efficient construction of intricate molecular structures, which are often found in biologically active natural compounds.
Overall, 1-ethylpropylzinc bromide's applications span across different areas of chemistry, with its primary use being in the synthesis of organic compounds and the development of pharmaceuticals and complex natural products. Its unique properties make it an indispensable tool for chemists working in these fields.
Check Digit Verification of cas no
The CAS Registry Mumber 308796-09-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,0,8,7,9 and 6 respectively; the second part has 2 digits, 0 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 308796-09:
(8*3)+(7*0)+(6*8)+(5*7)+(4*9)+(3*6)+(2*0)+(1*9)=170
170 % 10 = 0
So 308796-09-0 is a valid CAS Registry Number.
InChI:InChI=1/C5H11.BrH.Zn/c1-3-5-4-2;;/h5H,3-4H2,1-2H3;1H;/q;;+1/p-1/rC5H11BrZn/c1-3-5(4-2)7-6/h5H,3-4H2,1-2H3
308796-09-0Relevant academic research and scientific papers
Palladium-Catalyzed Cross-Coupling of Silyl Electrophiles with Alkylzinc Halides: A Silyl-Negishi Reaction
Cinderella, Andrew P.,Vulovic, Bojan,Watson, Donald A.
supporting information, p. 7741 - 7744 (2017/06/21)
We report the first example of a silyl-Negishi reaction between secondary zinc organometallics and silicon electrophiles. This palladium-catalyzed process provides direct access to alkyl silanes. The delicate balance of steric and electronic parameters of the employed DrewPhos ligand is paramount to suppressing isomerization and promoting efficient and selective cross-coupling.
Pd-PEPPSI-IPentCl: A highly effective catalyst for the selective cross-coupling of secondary organozinc reagents
Pompeo, Matthew,Hadei, Niloufar,Organ, Michael G.,Froese, Robert D. J.
, p. 11354 - 11357,4 (2012/12/12)
No migration? No problem. A series of new N-heterocyclic carbene based Pd complexes has been created and evaluated in the Negishi cross-coupling of aryl and heteroaryl chlorides, bromides, and triflates with a variety of secondary alkylzinc reagents (see scheme). The direct elimination product is nearly exclusively formed; in most examples there is no migratory insertion at all. Copyright
Pd-PEPPSI-IPentCl: A highly effective catalyst for the selective cross-coupling of secondary organozinc reagents
Pompeo, Matthew,Froese, Robert D. J.,Hadei, Niloufar,Organ, Michael G.
, p. 11354 - 11357 (2013/01/15)
No migration? No problem! A series of new N-heterocyclic carbene based Pd complexes has been created and evaluated in the Negishi cross-coupling of aryl and heteroaryl chlorides, bromides, and triflates with a variety of secondary alkylzinc reagents (see scheme). The direct elimination product is nearly exclusively formed; in most examples there is no migratory insertion at all. Copyright
