308803-91-0

Upstream product

• 140201-79-2 2-iodo-3-methoxy-5-methylbenzoyl chloride 
• 133344-02-2 2-iodo-3-methoxy-5-methylbenzoic acid 
• 61836-37-1 5-Methoxynaphthalene-1,4-diol 
• 4923-61-9 5-methoxynaphthoquinone 
• 77-78-1 dimethyl sulfate 
• 281190-83-8 4-hydroxy-5-methoxy-1-naphthyl 2-iodo-3-methoxy-5-methylbenzoate 

Relevant academic research and scientific papers

Annulation strategies for benzo[b]fluorene synthesis: efficient routes to the kinafluorenone and WS-5995 antibiotics.

Intramolecular palladium-mediated arylation approaches to benzo[b]fluorenes have been investigated. The methodology has been applied in a short synthesis of tri-O-methylkinafluorenone, providing an effective alternative to Friedel-Crafts-based approaches. During the course of this work, an acid-promoted quinolactonization of naphthoquinones was also developed, providing direct access to either ortho or para isomers as desired. Application of this methodology in syntheses of the antibiotics WS-5995A, WS-5995C, and functional analogues was demonstrated, and antitumoral activity of this class was determined.

Regioselective lactonization of naphthoquinones: Synthesis and antitumoral activity of the WS-5995 antibiotics

An acid promoted quinolactonization of naphthoquinones has been developed, providing direct access to either ortho or para isomers as desired. Application of this methodology in syntheses of the antibiotics WS- 5995A, WS-5995C and functional analogs is demonstrated. Preliminary antitumoral activity of the analogs is presented together with electrochemical analysis. (C) 2000 Elsevier Science Ltd.