133344-02-2

Upstream product

• 119650-46-3 2-Iodo-3-methoxy-5-methyl-benzoic acid methyl ester 
• 106116-42-1 1-bromomethyl-3-methoxy-5-methyl-benzene 
• 108593-44-8 methyl 3-methoxy-5-methylbenzoate 
• 119650-44-1 (3-methoxy-5-methylphenyl)methanol 
• 874-63-5 3,5-dimethylmethoxybenzene 
• 119650-45-2 (2-iodo-3-methoxy-5-methylphenyl)methanol 

Downstream Products

• 133344-06-6 5-(benzyloxy)-4-methoxynaphthalen-1-yl 2-iodo-3-methoxy-5-methylbenzoate 
• 140201-79-2 2-iodo-3-methoxy-5-methylbenzoyl chloride 
• 119650-51-0 1-benzyloxy-10,12-dimethoxy-8-methyl-6H-benzo[d]naphtho[1,2-b]pyran-6-one 
• 140201-80-5 2-Iodo-3-methoxy-5-methyl-benzoic acid 5-benzyloxy-8-[(2S,3R,4S,5R)-3,4-bis-benzyloxy-5-((S)-1-benzyloxy-ethyl)-tetrahydro-furan-2-yl]-4-methoxy-naphthalen-1-yl ester 
• 140201-81-6 1-Benzyloxy-4-[(2S,3R,4S,5R)-3,4-bis-benzyloxy-5-((S)-1-benzyloxy-ethyl)-tetrahydro-furan-2-yl]-10,12-dimethoxy-8-methyl-dibenzo[c,h]chromen-6-one 
• 140459-76-3 (+)-gilvocarcin M 
• 155351-67-0 1-(benzyloxy)-10,12-dimethoxy-8-methyl-4-(2,3,5-tri-O-benzyl-α-D-fucofuranosyl)-6H-benzonaphtho<1,2-b>pyran-6-one 
• 77879-89-1 gilvocarcin M 
• 308803-91-0 4,5-dimethoxy-1-naphthyl 2-iodo-3-methoxy-5-methylbenzoate 
• 281190-83-8 4-hydroxy-5-methoxy-1-naphthyl 2-iodo-3-methoxy-5-methylbenzoate 

Relevant academic research and scientific papers

Regioselective lactonization of naphthoquinones: Synthesis and antitumoral activity of the WS-5995 antibiotics

An acid promoted quinolactonization of naphthoquinones has been developed, providing direct access to either ortho or para isomers as desired. Application of this methodology in syntheses of the antibiotics WS- 5995A, WS-5995C and functional analogs is demonstrated. Preliminary antitumoral activity of the analogs is presented together with electrochemical analysis. (C) 2000 Elsevier Science Ltd.

Total synthesis of the gilvocarcins

Convergent total syntheses of the aryl C-glycoside antibiotics gilvocarcin M (1a) and gilvocarcin V (1b) have been accomplished. Key steps include (1) contrasteric coupling of D-fucofuranosyl acetate 27 with iodophenol 26, which was achieved by employing

A concise total synthesis of the aglycone of the gilvocarcins

A brief and convergent synthesis of the aglycone of the gilvocarcins M and E (and formally V) involving, in the key step, a Pd-mediated intramolecular biaryl coupling, is reported.