308807-17-2

Basic information

• Product Name: (2S)-2-tert-Butoxycarbonylamino-5,6-dimethylheptanoic acid
• Synonyms: (2S)-2-tert-Butoxycarbonylamino-5,6-dimethylheptanoic acid
• CAS NO: 308807-17-2
• Molecular Weight: 273.373
• Mol File: 308807-17-2.mol

Chemical Properties

• CAS DataBase Reference: (2S)-2-tert-Butoxycarbonylamino-5,6-dimethylheptanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (2S)-2-tert-Butoxycarbonylamino-5,6-dimethylheptanoic acid(308807-17-2)
• EPA Substance Registry System: (2S)-2-tert-Butoxycarbonylamino-5,6-dimethylheptanoic acid(308807-17-2)

Safety Data

• Hazardous Substances Data: 308807-17-2(Hazardous Substances Data)

Upstream product

• 5072-70-8 1-bromo-2,3-dimethyl-2-butene 

Relevant articles and documents

A new route to hydrophobic amino acids using copper-promoted reactions of serine-derived organozinc reagents

Copper-catalysed reaction of the serine-derived zinc reagent 1 with allylic electrophiles gives products arising formally from both SN2 and SN2′ pathways. These constitutional isomers can be separated, either directly, or in the case of (2S)-2-tert-butoxycarbonylamino-6-methylhept-5-enoic acid methyl ester (11) and (2S)-2-tert-butoxycarbonylamino-4,4-dimethylhex-5-enoic acid methyl ester (12) by selective epoxidation of 11. Hydrogenation of the double bond, followed by protecting group manipulation, allows the synthesis of the Fmoc-protected amino acids 3-7 ready for automated peptide synthesis. The Royal Society of Chemistry 2000.