308832-28-2

Upstream product

• 125967-80-8 Methanesulfonic acid (2R,3S,5R)-5-(5-methoxymethyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-trityloxymethyl-tetrahydro-furan-3-yl ester 
• 76-83-5 trityl chloride 
• 129580-08-1 3',5'-di-O-acetyl-5-(methoxymethyl)-2'-deoxyuridine 
• 5116-22-3 2'-deoxy-5-(methoxymethyl)uridine 
• 58589-18-7 3',5'-di-O-acetyl-5-bromomethyl-2'-deoxyuridine 
• 96829-18-4 5-methoxymethyl-5'-triphenylmethyl-2'-deoxyuridine 

Downstream Products

• 104639-39-6 5-methoxymethyl-1-(2'-deoxy-β-D-lyxofuranosyl)uracil 
• 125967-79-5 1-((2R,4R,5R)-4-Hydroxy-5-trityloxymethyl-tetrahydro-furan-2-yl)-5-methoxymethyl-1H-pyrimidine-2,4-dione 

Relevant academic research and scientific papers

A facile one-pot synthesis of 2,3'-anhydro-2'-deoxyuridines via 3'-O-imidazolylsulfonates

Continued interests in the novel synthetic methods of the pivotal compound, 2,3'-anhydro-2'-deoxyribonucleosides (7) uncovered a facile one-pot conversion of 5 with 1,1'-sulfonyldiimidazole in basic conditions to 7 with almost quantitative yields (91-99%).