30893-64-2

Usage

Uses

Used in Pharmaceutical and Medical Research:
2-(4-METHOXYPHENOXY)ACETAMIDE is used as a research compound for its analgesic and anti-inflammatory properties. It is particularly valuable in the development of new drugs targeting pain relief and inflammation reduction.
Used in Insecticide Development:
2-(4-METHOXYPHENOXY)ACETAMIDE is also being investigated for its potential use as an insecticide. Its unique structure and biological activities make it a candidate for the development of new insect control agents.
Used in Chemical Synthesis:
Due to its versatile structure, 2-(4-METHOXYPHENOXY)ACETAMIDE can be used as a building block in the synthesis of other organic compounds, contributing to the advancement of chemical research and the creation of novel pharmaceuticals.

InChI:InChI=1/C9H11NO3/c1-12-7-2-4-8(5-3-7)13-6-9(10)11/h2-5H,6H2,1H3,(H2,10,11)

Upstream product

• 150-76-5 4-methoxy-phenol 
• 79-07-2 Chloroacetamide 
• 1877-75-4 2-(4-methoxyphenoxy)acetic acid 

Downstream Products

• 50800-92-5 2-(4-methoxyphenoxy)ethylamine 

Relevant academic research and scientific papers

A phenoxy acetyl amine compound preparation method and phenoxy acetamide compounds

The invention belongs to the organic intermediates and the technical field of pharmaceutical intermediates, in particular to a phenoxy acetyl amine compound preparation method and phenoxy acetyl amine compound. The present invention provides a preparation method of the pervasive should be good, and green environmental protection, has better popularization and application value. The results show that the embodiment, the invention provides the above-mentioned method can prepare a plurality of phenoxy acetyl amine compound, and the yield can be 76%.

Synthesis and biological evaluation of 2-Phenoxyacetamide analogues, a novel class of potent and selective monoamine oxidase inhibitors

Monoamine oxidases (EC 1.4.3.4; MAOs), a family of FAD-containing enzymes, is an important target for antidepressant drugs. In this paper, a series of 2-phenoxyacetamide analogues were synthesized, and their inhibitory potency towards monoamine oxidases A (MAO-A) and B (MAO-B) were evaluated using enzyme and cancer cell lysate. 2-(4-Methoxyphenoxy)acetamide (compound 12) (SI = 245) and (2-(4-((prop-2- ynylimino)methyl)phenoxy)acetamide (compound 21) (IC50MAO-A = 0.018 μM, IC50MAO-B = 0.07 μM) were successfully identified as the most specific MAO-A inhibitor, and the most potent MAO-A/-B inhibitor, respectively. The inhibitory activities of these two compounds in living cells were also further evaluated utilizing HepG2 and SHSY-5Y cell lysates.

Discovery of a new series of 5-HT1A receptor agonists

Starting from compounds previously identified as α1-adrenoceptor antagonists that were also found to bind to the 5-HT1A receptor, in an attempt to separate the two activities, a new series of 5-HT1A receptor agonists was identified and shown to have high potency and/or high selectivity. Of these, compound 13, which combines high selectivity (5-HT1A/α1 = 151) and good agonist potency (pD2 = 7.82; Emax = 76), was found to be the most interesting.

Efficient method for the direct preparation of amides from carboxylic acids using tosyl chloride under solvent-free conditions

A simple, clean and highly efficient solvent-free procedure for the preparation of primary, secondary, tertiary and aromatic amides is described from the direct reaction of carboxylic acids and silica-supported ammonium salts, triethylamine (TEA) and tosyl chloride (TsCl) as condensing agent. The reaction proceeds rapidly in high yields at room temperature.