30894-74-7Relevant academic research and scientific papers
Combinatorial solid-phase synthesis of 4,6-diaryl and 4-aryl, 6-alkyl-1,3,5-triazines and their application to efficient biofuel production
Kim, Jaoon Y. H.,Lee, Jae Wook,Lee, Woo Sirl,Ha, Hyung-Ho,Vendrell, Marc,Bork, Jacqueline T.,Lee, Youngsook,Chang, Young-Tae
scheme or table, p. 395 - 398 (2012/09/05)
Herein we report the solid-phase synthesis of a combinatorial aryl, alkyl-triazine library and its application to biofuel production. The combination of Grignard reactions and solid supported Suzuki coupling reactions afforded unique 120 triazine compounds with high purities and minimum purification steps. Through an unbiased phenotypic screening for improved biofuel generation in oleaginous yeast, we found one diaryl triazine derivative (E4) which increased the biolipid production up to 86%.
Novel orthogonal synthesis of a tagged combinatorial triazine library via grignard reaction
Lee, Jae Wook,Bork, Jacqueline T.,Ha, Hyung-Ho,Samanta, Animesh,Chang, Young-Tae
experimental part, p. 1000 - 1006 (2010/03/01)
To expand the diversity of 1,3,5-triazine libraries to aryl and alkyl functionalities through the CC bond, we employed a novel orthogonal synthesis via Grignard monoalkylation or monoarylation of cyanuric chloride in solution to prepare aryl- or alkyl-substituted triazine building blocks. These aryl- or alkyl-substituted triazine building blocks were captured by a resin-bound amine, followed by amination and acidic cleavage with high purity. Herein, we demonstrate a novel orthogonal synthesis of a tagged aryl- and alkyl-triazine library on solid support, utilizing building blocks prepared via Grignard reaction in solution. Through incorporation of a triethylene glycol linker at one of the alternate sites on the triazine scaffold we explored an intrinsic tagged library approach. CSIRO 2009.
Anarchy in the solid state: structural dependence on glass-forming ability in triazine-based molecular glasses
Wuest, James D.,Lebel, Olivier
experimental part, p. 7393 - 7402 (2009/12/06)
We have recently shown that molecular glasses, small molecules capable of readily forming glassy solids as opposed to crystals, can be designed by exploiting molecular association through strong and directional intermolecular interactions, as exemplified by several members of the bis(mexylamino)triazine family. Herein, 43 new bis(mexylamino)triazine derivatives were synthesized, 31 of which have been found to spontaneously form glassy phases and did not crystallize upon heating. Crown Copyright
Synthesis and biological evaluation of novel 1,3,5-triazine derivatives as antimicrobial agents
Zhou, Chunhui,Min, Jaeki,Liu, Zhigang,Young, Anne,Deshazer, Heather,Gao, Tian,Chang, Young-Tae,Kallenbach, Neville R.
, p. 1308 - 1311 (2008/09/19)
Numerous studies have contributed to the development of natural and synthetic antimicrobial peptides as a prospective source of antibiotic agents. Based on the concept that cationic charge, bulk, and lipophilicity are major factors determining antibacterial activity in these peptides, we designed and screened several combinatorial libraries based on 1,3,5-triazine as a template. A set of compounds were identified to show potent antimicrobial activity together with low hemolytic activity.
S-TRIAZINE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USING THE SAME
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Page/Page column 36, (2009/01/20)
Novel s-triazine compounds are disclosed and represented by the following: formula (Ia). The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, where microbial infection is either a direct cause or a related condition.
2-Alkyl-4,6-dialkylamino-1,3,5-triazines via Grignard alkylation of cyanuric chloride: An aged reaction revisited
Menicagli, Rita,Samaritani, Simona,Zucchelli, Valeria
, p. 9705 - 9711 (2007/10/03)
Suitable one-pot reaction conditions are suggested to prepare, in good overall yields, some 2-(alk-1'-ynyl)- and 2-alkyl-4,6-dialkylamino-1,3,5-triazines via reaction of cyanuric chloride with Grignard reagents followed by amination. (C) 2000 Elsevier Science Ltd.
