30895-13-7

Usage

Tetrazole derivative

A chemical compound based on the tetrazoles structure, which is a five-membered heterocyclic ring containing four nitrogen atoms and one carbon atom.

3-fluorophenyl substituent

A molecular group consisting of a phenyl ring (a six-carbon ring with alternating single and double bonds) with a fluorine atom attached to the third carbon atom.

Widely used in organic synthesis

The compound is frequently employed as a building block or reagent in the synthesis of more complex organic molecules.

Medicinal chemistry applications

The compound has potential use in the development of pharmaceutical drugs due to its pharmacological properties.

Potential pharmacological properties

The compound is known for its possible therapeutic effects, particularly as an antitumor and antiviral agent.

Inhibits cancer cell growth

1-(3-fluorophenyl)-1H-tetrazol-5-amine has been studied for its ability to slow down or stop the growth of cancer cells.

Promising preclinical results

The compound has shown positive outcomes in preliminary studies conducted before testing on humans.

Antiviral activity

The compound has been explored for its potential to combat viruses, specifically herpes simplex virus and influenza virus.

Upstream product

• 14210-80-1 1-(3-fluoro-phenyl)-1H-tetrazole 
• 372-19-0 meta-fluoroaniline 

Relevant academic research and scientific papers

Controlling Pd-Catalyzed N-Arylation and Dimroth Rearrangement in the Synthesis of N,1-Diaryl-1 H-tetrazol-5-amines

The Pd-catalyzed N-arylation method for the synthesis of eighteen N,1-diaryl-1H-tetrazol-5-amine derivatives is reported. By running the reactions at 35 °C, compounds were isolated as single isomers since the undesired Dimroth rearrangement was completely

On the Physicochemical Characterization of 5-Amino-1-aryl-1H-tetrazoles: Electronic Molecule Parameters from the Thermal Isomerization into 5-Arylamino-1H-tetrazoles

The known thermal isomerization of 5-amino-1-aryl-1H-tetrazoles (A) into corresponding 5-arylamino-1H-tetrazoles (HB) was used to derive physicochemical parameters characterizing the electronic substituent effect on isomerism and dissociation equilibria. For a series of 26 tetrazoles A as starting materials the equilibrium constants (pKi) of isomerization in boiling ethylene glycol at 197°C and the dissociation constants (pKa) of the NH-acidic tetrazoles HB were determined by potentiometric titration of rapidly cooled equilibrium mixtures in water and ethanol/water with KOH at 25°C. The pK values are closely correlated with Hammett's electronic substituent constants σ and can be used as electronic molecule parameters in QSAR or QSPR (QSAR = quantitative structure-activity relationship; QSPR = quantitative structure-property relationship) studies.