30906-06-0

Basic information

• Product Name: methyl 12-acetoxyabieta-6,8,11,13-tetraen-18-oate
• CAS NO: 30906-06-0
• Molecular Weight: 372.505
• Mol File: 30906-06-0.mol

Chemical Properties

• CAS DataBase Reference: methyl 12-acetoxyabieta-6,8,11,13-tetraen-18-oate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 12-acetoxyabieta-6,8,11,13-tetraen-18-oate(30906-06-0)
• EPA Substance Registry System: methyl 12-acetoxyabieta-6,8,11,13-tetraen-18-oate(30906-06-0)

Safety Data

• Hazardous Substances Data: 30906-06-0(Hazardous Substances Data)

Upstream product

• 55623-34-2 (1R,4aR)-7-Isopropyl-1,4a-dimethyl-6-oxo-1,2,3,4,4a,4b,5,6,10,10a-decahydro-phenanthrene-1-carboxylic acid methyl ester 
• 64-19-7 acetic acid 

Downstream Products

• 13742-23-9 (1R,4aS)-6-Hydroxy-7-isopropyl-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydro-phenanthrene-1-carboxylic acid methyl ester 
• 22595-48-8 18-Hydroxyferruginol 
• 13742-23-9 (1R,4aS,10aR)-6-Hydroxy-7-isopropyl-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydro-phenanthrene-1-carboxylic acid methyl ester 

Relevant articles and documents

Synthesis of 4- epi-Parviflorons A, C, and E: Structure-Activity Relationship Study of Antiproliferative Abietane Derivatives

The first syntheses of 4-epi-parviflorons A, C, and E (4-epi-1-3) were achieved in 12-13 steps from commercially available (-)-abietic acid (5). All synthesized compounds, including intermediates and derivatives, were evaluated for antiproliferative activity against five human tumor cell lines. A structure-activity relationship study revealed no significant difference between Pf E and 4-epi-Pf E, the importance of two oxygen functional groups at C-11 and C-12 for antiproliferative activity, as well as a combination of carbomethoxy at C-4 and a benzoyl ester with electron-drawing group at C-12 or hydroxymethyl at C-4 and an appropriate oxidation state of ring-B/C for triple-negative breast cancer cell selectivity.