309241-44-9Relevant academic research and scientific papers
METHOD FOR PRODUCING SANSHOOL
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Paragraph 0127; 0128; 0129, (2013/09/26)
Provided are a method for producing a sanshool, which method has a short process and exhibits high stereoselectivity, as well as an iron carbonyl complex compound that is an intermediate useful for the production method. A diene iron complex compound characterized by being represented by the following general formula (I): (in which A represents CO, P(RA)3, CN, NO, SO(RA)3, or N(RA)2; RA represents a straight chain or branched chain alkyl group having 1 to 4 carbon atoms or an aryl group having 6 to 12 carbon atoms; and one of R1 and R2 represents a hydrogen atom and the other one thereof represents a structure represented by the following formula (II)): (in which R represents a hydrogen atom, a hydroxyl group, or a methyl group).
Application of iron carbonyl complexation to the selective total synthesis of sanshools
Aoki, Katsuyuki,Igarashi, Yasushi,Nishimura, Hiroaki,Morishita, Isao,Usui, Kimitoshi
supporting information, p. 6000 - 6003 (2013/01/13)
We focused on the iron-complexes of sanshools (hydroxyl-α-sanshool, hydroxyl-β-sanshool, and γ-sanshool) as the key intermediates for the selective synthesis of these structurally unstable compounds. Consequently, we developed a concise and selective method for the total synthesis of sanshools in 5-6 steps (26-45% overall yield), including complexation of dienes with iron tricarbonyl group.
THIOREDOXIN AND THIOREDOXIN REDUCTASE INHIBITORS
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Page/Page column 58; 13/22; 14/22, (2008/06/13)
The present invention relates to sulfone derivatives and to their use as modulators of the thioredoxin/thioredoxin reductase redox system, including for the treatment and/or prevention of pathophysiological conditions mediated by thioredoxin/thioredoxin reductase, such as cancer, HIV/ AIDS, Alzheimer's disease, rheumatoid arthritis, and skin disorders. Also provided are pharmaceutical compositions comprising the inventive sulfones.
Towards the synthesis of amphidinolide B. An intramolecular stille coupling approach
Belen Cid,Pattenden
, p. 7373 - 7378 (2007/10/03)
A synthetic approach towards the cytotoxic polyene polyol macrolide amphidinolide B (1), based on elaboration of the C1-C13 carboxylic acid 4. and the C14-C25 alcohol 3 units, their esterification to the iodostannyl ester 2, and an intramolecular Stille sp2-sp2 coupling reaction, is described. In spite of adequate precedent and model experiments, circumstances conspired and the aforementioned coupling reaction was not realised in this case. (C) 2000 Elsevier Science Ltd.
