309731-12-2Relevant academic research and scientific papers
N-Substituted tetrahydro-1,3-oxazines and oxazolidines 1. A new version of the Mannich reaction involving amino alcohols
Korepin,Galkin,Glushakova,Lagodzinskaya,Loginova,Lodygina,Eremenko
, p. 104 - 109 (2001)
A new version of the Mannich reaction involving amino alcohols (3-aminopropan-1-ol and aminoethanol) was developed. These compounds react with formaldehyde and CH or NH acids to give N-substituted tetrahydro-1,3-oxazines or oxazolidines.
New N-nitrosoamines 1. Synthesis and nitrosative cleavage of the Mannich bases derived from nitrogen-containing heterocycles and primary aliphatic amines
Korepin,Galkin,Glushakova,Lodygina,Eremenko,Nefedov,Eremenko
, p. 1630 - 1638 (2001)
The reactions of isatin, benzotriazole, and succinimmide with formaldehyde and methylamine yield monoamines RCH2N(Me)CH2R and methylenediamines RCH2N(Me)CH2N(Me)CH2R. The use of ethylenediamine as the amino component affords N,N′ -disubstituted imidazolidines, while the reactions with 3-aminopropan-1-ol give N-substituted tetrahydro-1.3-oxazines. RCH2NBu12 was obtained from succinimide, formaldehyde, and diisobutylamine. Nitrosative cleavage of the amines obtained was studied: it was shown that monoamines and methylenediamines give N-nitrosoamines RCH2N(NO)Me, which were structurally characterized by X-ray diffraction analysis. RCH2NBu12 affords diisobutylnitrosamine, while imidazolidines transform into dinitroso compounds RCH2N(NO)CH2CH2N(NO)CH2R.
