309733-25-3Relevant academic research and scientific papers
Microwave-assisted benzyl mono- and dibromination in diethyl carbonate as environmentally friendly alternative to radical bromination in carbon tetrachloride
Pingali, Subramanya R. K.,Upadhyay, Sunil K.,Jursic, Branko S
experimental part, p. 928 - 933 (2011/05/15)
An environmentally friendly benzyl mono- and di-bromination synthetic procedure was developed that is superior to the classic carbon tetrachloride bromination procedure in both reaction time and isolated yield. This new reaction was performed in diethyl carbonate as reaction media using microwave instead of conventional heating. Both the solvent and the brominating reagent N-bromosuccinimide (prepared from succinimide obtained from the reaction mixture) are recyclable. Practically, the preparation of our target compounds was completed in less than two hours. The Royal Society of Chemistry.
Microwave-assisted NBS bromination of p-iminotoluenes: Preparation of new alcohol, mercapto, and amino protection groups
Upadhyay, Sunil K.,Jursic, Branko S.
experimental part, p. 3177 - 3185 (2011/09/20)
A simple, efficient, safe, high-yielding and rapid microwave-assisted method for the preparation of protected p-bromomethyl and p- dibromomethylanilines was developed as new alcohol, thiol, and amine protection groups. The procedure involves microwave-assisted N-bromosuccinimide (NBS) radical bromination of readily available N-protected p-toluidine. The microwave-assisted radical bromination was found to be superior to the conventional NBS radical bromination. Copyright
A convenient method for the preparation of benzyl isocyanides
Kitano, Yoshikazu,Manoda, Tetsuya,Miura, Teppei,Chiba, Kazuhiro,Tada, Masahiro
, p. 405 - 410 (2007/10/03)
Treatment of benzyl halides with silver salts (AgClO4, AgBF 4, or AgOTf) and trimethylsilyl cyanide (TMSCN) in CH 2Cl2 followed by cleavage of the carbon-silicon bond with aqueous NaHCO3 or TBAF directly afforded the corresponding isocyanides. Georg Thieme Verlag Stuttgart.
A simple key for benzylic mono- and gem-dibromination of primary aromatic amine derivatives using molecular bromine1
Kar, Anirban,Argade, Narshinha P.
, p. 221 - 224 (2007/10/03)
Quantitative benzylic mono- and gem-dibromination on primary aromatic amine derivatives have been achieved using molecular bromine and by protecting the amino group as a succinimide moiety. The reactions of N-(o/m/p-tolyl)succinimides 5a-c with 1.25 equiv
