309756-60-3Relevant articles and documents
Stereoselective Michael additions on α-aminoacrylates as the key step to an l-Oic analogue bearing a quaternary stereocenter
Cecchinelli, Federico Maria,Celentano, Giuseppe,Gaggero, Nicoletta,Puglisi, Alessandra
, p. 671 - 674 (2020)
A novel, highly stereoselective route for pharmaceutically relevant octahydroindole-2-carboxylates bearing a quaternary stereocenter has been developed. The key chiral intermediates 3 have been prepared in good yields and enantiomeric excesses up to 98%. A broad substrate range has been tolerated under the reaction conditions.
Intramolecular reductive ketone-alkynoate coupling reaction promoted by (η2-propene)titanium
Schaefer, Christian,Miesch, Michel,Miesch, Laurence
supporting information; scheme or table, p. 3253 - 3257 (2012/06/01)
Intramolecular reductive coupling of cycloalkanones tethered to alkynoates in the presence of (η2-propene)titanium was successfully performed to provide hydroxy-esters in a diastereoselective manner. Subsequent lactonization afforded angularly
Enantioselective synthesis of a simple benzenoid analogue of glycinoeclepin a
Giroux, Simon,Corey
supporting information; experimental part, p. 5617 - 5619 (2009/06/18)
(Chemical Equation Presented) A synthesis of the readily accessible glycinoeclepin A analogue 2 is reported.
Carbocyclic α-amino acids: Asymmetric Strecker synthesis of a series of 2-alkylated 1-aminocyclopentanecarboxylic acids
Wede, Judith,Volk, Franz-J.,Frahm, August W.
, p. 3231 - 3252 (2007/10/03)
A series of 12 carbocyclic α-amino acids has been prepared from four different racemic 2-alkylated cyclopentanones and (R)-1-phenylethylamine as the chiral auxiliary by means of an asymmetric Strecker synthesis. The stereoselectivity was influenced by sol
Asymmetric Reductive Amination of Cycloalkanones, 5. Synthesis and Absolute Configuration of 2-Substituted Cyclopentanamines
Wiehl, Wolfgang,Frahm, August W.
, p. 2668 - 2677 (2007/10/02)
In an asymmetric synthesis 2-substituted cyclopentanamines are obtained from racemic cyclopentanones by means of reductive amination in a three-step procedure.Condensation of the ketones 3(n) with optically active 1-phenylethylamines yields imine mixtures