309757-66-2Relevant academic research and scientific papers
Rhodium-catalyzed heck-type coupling of boronic acids with activated alkenes in an aqueous emulsion
Lautens, Mark,Mancuso, John,Grover, Harpreet
, p. 2006 - 2014 (2004)
Intermolecular couplings between arylboronic acids and activated alkenes catalyzed by a water-soluble tert-bulyl amphosrhodium complex were found to progress at room temperature and generated Heck-type products with high yields and excellent selectivity. Substitution on the alkene component encouraged the formation of products arising from a conjugate addition-protonation process. In the case of Heck product formation, it was necessary to add two equivalents of the alkene component whereby one equivalent is believed to act as a sacrificial hydride acceptor.
Asymmetric synthesis of β-haloaryl β-amino acid derivatives
Bull, Steven D.,Davies, Stephen G.,Delgado-Ballester, Santiago,Kelly, Peter M.,Kotchie, Luke J.,Gianotti, Massimo,Laderas, Mario,Smith, Andrew D.
, p. 3112 - 3121 (2007/10/03)
Lithium N-benzyl-N-α-methyl-4-methoxybenzylamide may be employed as a homochiral ammonia equivalent for the synthesis of homochiral β-haloaryl β-amino acid derivatives via a strategy involving its conjugate addition to α,β-unsaturated β-haloaryl acceptors and subsequent oxidative deprotection with ceric ammonium nitrate.
