309761-65-7Relevant academic research and scientific papers
Mimics of ganglioside GM1 as cholera toxin ligands: replacement of the GalNAc residue.
Bernardi, Anna,Arosio, Daniela,Manzoni, Leonardo,Monti, Diego,Posteri, Helena,Potenza, Donatella,Mari, Silvia,Jimenez-Barbero, Jesus
, p. 785 - 792 (2007/10/03)
Two new cholera toxin (CT) ligands (4 and 5) are described. The new ligands were designed starting from the known GM1 mimics 2 and 3 by replacement of their GalNAc residue with the C4 isomer GlcNAc. As predicted by molecular modelling, the conformational
Second generation mimics of ganglioside GM1 as artificial receptors for cholera toxin: Replacement of the sialic acid moiety
Bernardi, Anna,Carrettoni, Laura,Ciponte, Antonio Grosso,Monti, Diego,Sonnino, Sandro
, p. 2197 - 2200 (2007/10/03)
In a program directed towards the design and synthesis of mimics of ganglioside GM1, the NeuAc recognition domain was replaced by simple hydroxy acids, and the affinity of the new ligands to the cholera toxin was determined by fluorescence spectroscopy. T
