30980-47-3Relevant academic research and scientific papers
Tetrakis(trimethylsilyl)silane-Mediated Photochemical Alkylation of Heteroaromatic Bases with Alkyl Halides
Togo, Hideo,Hayashi, Ken,Yokoyama, Masataka
, p. 2063 - 2064 (1991)
Alkyl halides reacted with protonated heteroaromatic bases in the presence of tetrakis(trimethylsilyl)silane (TTMS) under irradiation with high pressure mercury lamp to give the corresponding alkylated heteroaromatic bases.This is the first report on the
The Alkylation and Reduction of Heteroarenes with Alcohols Using Photoredox Catalyzed Hydrogen Atom Transfer via Chlorine Atom Generation
Zidan, Montserrat,Morris, Avery O.,McCallum, Terry,Barriault, Louis
supporting information, p. 1453 - 1458 (2019/08/01)
Radical additions to heteroaromatic bases are frequently employed for the rapid synthesis of complex products using C–H functionalization strategies. The conditions that are commonly employed are typically harsh, routinely requiring stoichiometric oxidants and other additives. In search for milder reaction environments allowing late-stage functionalization, we present the alkylation of N-heteroarenes using primary alcohols and ethers as radical precursors, where the corresponding alkyl radical is formed via hydrogen atom transfer process with a photoredox catalyzed chlorine atom generation as HAT agent. Furthermore, we explore the reduction of the heteroarenes in moderate to high yields when using secondary alcohols.
Recyclable catalytic synthesis of substituted quinolines: copper-catalyzed heterocyclization of 1-(2-aminoaryl)-2-yn-1-ols in ionic liquids
Gabriele, Bartolo,Mancuso, Raffaella,Lupinacci, Elvira,Spina, Rosella,Salerno, Giuseppe,Veltri, Lucia,Dibenedetto, Angela
experimental part, p. 8507 - 8512 (2010/01/06)
A convenient and simple approach for the recyclable catalytic synthesis of substituted quinolines is presented. The method is based on CuCl2-catalyzed heterocyclization of readily available 1-(2-aminoaryl)-2-yn-1-ols in BmimBF4 as the solvent at 100 °C for 15-24 h. The solvent-catalyst system could be successfully recycled up to six times without significant loss of activity.
A NEW GENERAL METHOD OF HOMOLYTIC ALKYLATION OF PROTONATED HETEROAROMATIC BASES
Castaldi, Graziano,Minisci, Francesko,Tortelli, Vito,Vismara, Elena
, p. 3897 - 3900 (2007/10/02)
Alkyl iodides and benzoyl peroxides provide a new general method of homolytic alkylation of protonated heteroaromatic bases.Yields are good and the substitution is selective in the positions ortho and para to the heteroatom.
