30987-77-0Relevant academic research and scientific papers
Modification of quercetin by (dodecylsulfanyl)methyl group
Bagavieva,Yagunov,Kholshin,Prosenko
, p. 194 - 196 (2019)
A simple and efficient synthetic protocol for alkylthiomethylation of quercetin was proposed. New sulfur-containing quercetin derivatives were obtained by the reaction of this flavonoid with (N,N-diethylaminomethyl)dodecyl sulfide.
Mannich aminomethylation of flavonoids and anti-proliferative activity against breast cancer cell
Hoang, T. Kim-Dung,Huynh, T. Kim-Chi,Do, T. Hong-Tuoi,Nguyen, Thanh-Danh
, p. 1399 - 1406 (2018/06/01)
We herein report Mannich aminomethylation of variously structural flavonoids and their biological evaluation against human breast cancer cell. Mannich reaction showed that substitution at C-6 position depends on amine basicity and C-ring feature of flavon
ANTIOXIDANT FLAVONOID DERIVATIVES
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Paragraph 0057, (2014/07/23)
The present invention relates to antioxidant flavonoids, compositions containing such antioxidant flavonoids and methods for using such antioxidant flavonoids to treat, e.g., AMD.
Synthesis of antioxidants for prevention of age-related macular degeneration
Joshi, Dharati,Field, James,Murphy, John,Abdelrahim, Mohammed,Schoenherr, Heike,Sparrow, Janet R.,Ellestad, George,Nakanishi, Koji,Zask, Arie
, p. 450 - 454 (2013/05/08)
Photooxidation of A2E may be involved in diseases of the macula, and antioxidants could serve as therapeutic agents for these diseases. Inhibitors of A2E photooxidation were prepared by Mannich reaction of the antioxidant quercetin. These compounds contai
Nitrogen-containing flavonoid analogues as CDK1/cyclin B inhibitors: Synthesis, SAR analysis, and biological activity
Zhang, Shixuan,Ma, Jigang,Bao, Yongming,Yang, Puwen,Zou, Liang,Li, Kangjian,Sun, Xiaodan
, p. 7128 - 7133 (2008/12/22)
A series of nitrogen-containing flavonoid analogues were designed and synthesized by Mannich reaction, and screened for the inhibitory activities of cyclin-dependent kinases using a FRET-based biochemical assay method. The results showed that C-8 nitrogen-containing baicalein analogues 3a-3f exhibited potent CDK1/Cyclin B inhibitory activities. 5,6,7-Trihydroxy-8-(dimethylaminomethyl)-2-phenyl-4H-chromen-4-one 3a, 5,6,7-trihydroxy-8-(pyrrolid inylmethyl)-2-phenyl-4H-chromen-4-one 3b, and 5,6,7-trihydroxy-8-(piperidinylmethyl)-2-phenyl-4H-chromen-4-one 3c (IC50 1.05-1.28 μM) were about sixfold more potent than baicalein 2 (IC50 6.53 μM). 5,6,7-Trihydroxy-8-(morpholinomethyl)-2-phenyl-4H-chromen-4-one 3d, 5,6,7-trihydroxy-8-(thiomorpholinomethy)-2-phenyl-4H-chrom en-4-one 3e, and 5,6,7-trihydroxy-8-(4-methylpiperazinylmethyl)-2-phenyl-4H-chromen-4-one 3f (IC50 0.27-0.38 μM) were about 20-fold more potent than baicalein, and were at the same level as flavopiridol (IC50 0.33 μM).
