30989-81-2

Basic information

• Product Name: 3-AMINO-2-METHYLACRYLALDEHYDE
• Synonyms: 3-AMINO-2-METHYLACRYLALDEHYDE;3-AMINO-2-METHACRYLALDEHYDE;3-Amino-2-methylprop-2-enal;3-Amino-2-methylacrylaldehyde, 3-Amino-2-methylacrolein;4-aMino-3-Methyl-2-oxobut-3-enal;3-AMINO-2-METHYLACROLEIN
• CAS NO: 30989-81-2
• Molecular Formula: C₄H₇NO
• Molecular Weight: 85.1
• Product Categories: Aliphatics;Amines
• Mol File: 30989-81-2.mol
• Article Data: 5

Chemical Properties

• Melting Point: 101 °C
• Boiling Point: 278.5 °C at 760 mmHg
• Flash Point: 122.3 °C
• Appearance: /
• Density: 0.956g/cm³
• Vapor Pressure: 0.00424mmHg at 25°C
• Refractive Index: 1.456
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3-AMINO-2-METHYLACRYLALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-AMINO-2-METHYLACRYLALDEHYDE(30989-81-2)
• EPA Substance Registry System: 3-AMINO-2-METHYLACRYLALDEHYDE(30989-81-2)

Safety Data

• Hazard Codes: Xi
• Statements: 20/21/22-34
• Safety Statements: 26-36/37/39
• RIDADR: 2923
• Hazardous Substances Data: 30989-81-2(Hazardous Substances Data)

Usage

General Description

3-Amino-2-methylacrylaldehyde, also known as 2-Amino-3-methylacrylaldehyde or AMA, is an organic compound with the chemical formula C4H7NO. It is a yellow liquid with a pungent odor, and is primarily used as a key intermediate in the synthesis of pharmaceuticals, agrochemicals, and fine chemicals. AMA is also a versatile building block in organic synthesis, and is used in the production of various resin and polymer products. It is categorized as a reactive aldehyde, and its chemical reactivity makes it an important precursor in the creation of a wide range of organic compounds with various functional groups. Additionally, AMA is known to exhibit antimicrobial and anti-inflammatory properties, making it a valuable compound in the development of new drugs and pharmaceuticals.

InChI:InChI=1/C4H7NO/c1-4(2-5)3-6/h2-3H,5H2,1H3/b4-2+

Upstream product

• 42588-57-8 3-ethoxymethacrolein 

Downstream Products

• 85147-10-0 2,4-Diamino-6-methylpyrido<2,3-d>pyrimidine 
• 2036-41-1 5-methylpyrimidine 
• 7554-65-6 4-methyl-1H-pyrazole 
• 930272-56-3 2-(tert-butoxycarbonyl-aminomethyl)-5-methylpyrimidine 

Relevant articles and documents

BENZODIAZEPINE DERIVATIVES, COMPOSITIONS, AND METHODS FOR TREATING COGNITIVE IMPAIRMENT

This invention relates to benzodiazepine derivatives, compositions comprising therapeutically effective amounts of those derivatives and methods of using those derivatives or compositions in treating cognitive impairment associated with CNS disorders. It also relates to the use of an α5-containing GABAA receptor agonist (e.g., an α5-containing GABAA receptor positive allosteric modulator) in treating cognitive impairment associated with CNS disorders in a subject in need or at risk thereof, including age-related cognitive impairment, Mild Cognitive Impairment (MCI), amnestic MCI, Age-Associated Memory Impairment, Age Related Cognitive Decline, dementia, Alzheimer's Disease(AD), prodromal AD, PTSD, schizophrenia, bipolar disorder, ALS, cancer-therapy-related cognitive impairment, mental retardation, Parkinson's disease, autism spectrum disorders, fragile X disorder, Rett syndrome, compulsive behavior, and substance addiction. It also relates to the use of an α5-containing GABAA receptor agonist (e.g., an α5-containing GABAA receptor positive allosteric modulator) in treating brain cancers (including brain tumors, e.g., medulloblastomas), and cognitive impairment associated therewith.

A N - 2 - pyridyl -5 - pyrimidine preparation of method (by machine translation)

The invention relates to a pesticide in the technical field, and discloses a N - 2 - pyridyl - 5 - pyrimidine preparation of method, comprises the following steps: the 3 - ethoxy - 2 - methyl acrolein with ammonia ammoniation reaction to produce 3 - amino - 2 - methacrolein, the quality of the ammonia concentration is 20 - 25%, the 3 - ethoxy - 2 - methyl acrolein and ammonia in a molar ratio of 1: 1.0 - 1.5: 1.0 - 6.0. The N - 2 - pyridyl - 5 - pyrimidine preparation of method, by 3 - ethoxy - 2 - methyl acrolein as the starting material, through the ammoniation, cyclizes and brominated to obtain 5 - bromo methyl pyrimidine, then with 2 - aminopyridine reaction to obtain the target product, this invention adopts the cheap and easy to obtain 3 - ethoxy acrolein, in conventional process compared with the use of expensive 5 - pyrimidine formaldehyde, and greatly reduces the production cost, at the same time the invention the preparation method has the advantage of high yield, low cost, high efficiency in the production of more, in low-cost cases can prepare more N - 2 - pyridyl - 5 - pyrimidine methylamine, high practicability. (by machine translation)

BENZODIAZEPINE DERIVATIVES, COMPOSITIONS, AND METHODS FOR TREATING COGNITIVE IMPAIRMENT

This invention relates to benzodiazepine derivatives, compositions comprising therapeutically effective amounts of those benzodiazepine derivatives and methods of using those derivatives or compositions in treating cognitive impairment associated with central nervous system (CNS) disorders. In particular, it relates to the use of a a5- containing GABAA receptor agonist (e.g., a α5 -containing GABAA receptor positive allosteric modulator) as described herein in treating cognitive impairment associated with central nervous system (CNS) disorders in a subject in need or at risk thereof, including, without limitation, subjects having or at risk for age-related cognitive impairment, Mild Cognitive Impairment (MCI), amnestic MCI (aMCI), Age-Associated Memory Impairment (AAMI), Age Related Cognitive Decline (ARCD), dementia, Alzheimer's Disease(AD), prodromal AD, post traumatic stress disorder (PTSD), schizophrenia, bipolar disorder, amyotrophic lateral sclerosis (ALS), cancer-therapy-related cognitive impairment, mental retardation, Parkinson's disease (PD), autism spectrum disorders, fragile X disorder, Rett syndrome, compulsive behavior, and substance addiction.