30992-65-5

Usage

Uses

Used in Organic Synthesis:
4-Hydroxy-6-benzyloxycoumarin is used as a key intermediate in organic synthesis for the preparation of various pharmaceuticals, agrochemicals, and other specialty chemicals. Its unique structure allows for further functionalization and modification, making it a versatile building block in the synthesis of complex organic molecules.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 4-Hydroxy-6-benzyloxycoumarin is used as a starting material for the development of new drugs with potential therapeutic applications. Its chemical properties enable the design and synthesis of novel drug candidates with improved pharmacological properties, such as enhanced bioavailability, selectivity, and potency.
Used in Agrochemical Industry:
4-Hydroxy-6-benzyloxycoumarin also finds applications in the agrochemical industry, where it serves as a precursor for the synthesis of bioactive compounds with pesticidal properties. These compounds can be used in the development of new pesticides and herbicides, contributing to more effective and environmentally friendly agricultural practices.
Used in Specialty Chemicals:
In the specialty chemicals sector, 4-Hydroxy-6-benzyloxycoumarin is utilized for the production of various high-value chemicals, such as dyes, fragrances, and flavorings. Its unique structure and reactivity make it an attractive candidate for the synthesis of these specialty chemicals, which are used in a wide range of applications, including cosmetics, food, and beverages.

Upstream product

• 30992-63-3 5-benzyloxy-2-hydroxyacetophenone 
• 105-58-8 Diethyl carbonate 
• 103-16-2 4-Benzyloxyphenol 

Relevant academic research and scientific papers

Copper(II)-Catalyzed Tandem Reaction: Synthesis of Furo[3,2- c]coumarin Derivatives and Evaluation for Photophysical Properties

An efficient protocol for synthesizing furo[3,2-c]coumarin derivatives is described. The novel reaction could afford the desired furocoumarins with good to excellent yields in a mild and rapid manner. Large substrate scope screening and scale-up preparation have also been accomplished, and selected compounds were evaluated for their photophysical properties.

One-pot two-step synthesis of 3-iodo-4-aryloxy coumarins and their Pd/C-catalyzed annulation to coumestans

An efficient protocol for the synthesis of various coumestans from the intramolecular annulation of 3-iodo-4-aryloxy coumarins through C-H activation has been developed. When 3-iodo-4-aryloxy coumarins were treated with 10% Pd/C (0.3 mol% Pd) in the presence of sodium acetate, the corresponding coumestans were produced in good to excellent yield. Reusability of the palladium catalyst was investigated in up to three consecutive cycles and it was found that the yield of the reaction was almost unaltered. Sequential iodination and O-arylation of 4-hydroxy coumarins leading to the 3-iodo-4-aryloxy coumarins were also achieved in a one-pot two-step process starting from aryl iodides in high yield. Pivalic acid was revealed to be the most effective additive for the later method to produce 3-iodo-4-phenoxy coumarins. Different functional groups bearing electron-donating as well as withdrawing groups are also tolerant to the reaction conditions.

Coumarin derivatives for the treatment of allergies

Pharmaceutical compositions for the treatment of allergies are produced using coumarin derivatives as the active agent. Certain of these compounds and their salts are novel.