309927-00-2

Upstream product

• 100-83-4 meta-hydroxybenzaldehyde 
• 109-77-3 malononitrile 
• 4344-87-0 3-hydroxy-5-methyl-1H-pyrazole 
• 623-48-3 ethyl iodoacetae 
• 141-97-9 ethyl acetoacetate 
• 7803-57-8 hydrazine hydrate 
• 105-45-3 acetoacetic acid methyl ester 
• 7255-96-1 2-(3-hydroxybenzylidene)malononitrile 
• 108-26-9 3-methyl-2-pyrazoline-5-one 

Relevant academic research and scientific papers

Synthesis of pyranopyrazole derivatives by in situ generation of trityl carbocation under mild and neutral media

Abstract: In this work, synthesis of pyranopyrazole derivatives by the one-pot tandem four component condensation reaction of aryl aldehydes with ethyl acetoacetate, malononitrile, and hydrazine hydrate in the presence of Ph3CCl at 60?°C under

Design and development of a new functionalized cellulose-based magnetic nanocomposite: preparation, characterization, and catalytic application in the synthesis of diverse pyrano[2,3-c]pyrazole derivatives

In this work, a facile protocol for the preparation of a new cellulose-based functionalized magnetic nanocomposite catalyst is described. The structure and morphology of the prepared nanomaterial was characterized by scanning electron microscopy, energy-d

Synthesis of pyranopyrazoles using nano-Fe-[phenylsalicylaldiminemethylpyranopyrazole]Cl2 as a new Schiff base complex and catalyst

By the condensation reaction of benzaldehyde with ethyl acetoacetate, malononitrile and hydrazine hydrate in the presence of FeCl2, a pyranopyrazole derivative was prepared which was then reacted with salicylaldehyde to afford nano-Fe-[phenylsalicylaldiminemethylpyranopyrazole]Cl2 (nano-[Fe-PSMP]Cl2). The prepared nano-Schiff base complex was fully characterized using Fourier transform infrared spectroscopy, X-ray diffraction, thermogravimetric analysis, differential thermogravimetry, scanning electron microscopy and UV–visible spectroscopy, and was used as an efficient and catalyst for the preparation of pyranopyrazoles.

Synthesis, screening and docking of fused pyrano[3,2-d]pyrimidine derivatives as xanthine oxidase inhibitor

In view of developing effective xanthine oxidase (XO) enzyme inhibitors, a series of 100 pyrano[3,2-d]pyrimidine derivatives was synthesized and evaluated for its in vitro XO enzyme inhibition. Structure activity relationship has also been established. Am

Synthesis of pyrano[2,3-c]pyrazole derivatives using Fe3O4@SiO2@piperidinium benzene-1,3-disulfonate (Fe3O4@SiO2 nanoparticle-supported IL) as a novel, green and heterogeneous catalyst

A simple, green and efficient protocol for the one-pot four-component synthesis of pyrano[2,3-c]pyrazole derivatives produced from reaction between aryl aldehydes, ethyl acetoacetate, malononitrile and hydrazine hydrate in the presence of nano magnetic piperidinium benzene-1,3-disulfonate was synthesized in water at 60 °C. The Fe3O4@SiO2 nanoparticle-supported IL was designed and synthesized. The present process offers advantages such as clean reaction, short reaction time, good to excellent yield, easy purification and easy recoverable catalyst.

A green and clean pathway: One pot, multicomponent, and visible light assisted synthesis of pyrano[2,3-: C] pyrazoles under catalyst-free and solvent-free conditions

A mild, eco-efficient and metal-free synthetic protocol for the production of biologically significant scaffold dihydropyrano[2,3-c]pyrazoles via reaction between ethylacetoacetate (1), hydrazine hydrate (2), aromatic aldehydes (3) and malononitrile (4) a

Catalytic application of 1-(carboxymethyl)pyridinium iodide on the synthesis of pyranopyrazole derivatives

In this investigation, acetic acid functionalized pyridinium salt, namely 1-(carboxymethyl)pyridinium iodide {[cmpy]I}, has been introduced as reusable catalyst for green, simple and efficient synthesis of 6-amino-4-(4-methoxyphenyl)-5-cyano-3-methyl-1-ph

Screening of a library of 4-aryl/heteroaryl-4H-fused pyrans for xanthine oxidase inhibition: Synthesis, biological evaluation and docking studies

A series of 4-aryl/heteroaryl-4H-fused pyrans was synthesized via multicomponent reaction in a microwave synthesizer. All the pyrans were evaluated for in vitro xanthine oxidase inhibition. Structure-activity relationship was also established. Among the s

Cinnamomum tamala leaf extract-mediated green synthesis of Ag nanoparticles and their use in pyranopyrazles synthesis

A novel, biochemical, and eco-friendly method has been developed for the synthesis of Ag nanoparticles using an aqueous leaf extract of readily accessible Cinnamomum tamala as reducing and stabilizing agents. These Ag nanoparticles were used to catalyze t

An efficient organocatalyst for environmentally benign synthesis of pyranopyrazole derivatives in aqueous medium

The use of multicomponent reactions as potential synthetic processes, ionic liquids as catalysts and water as reaction medium is a suitable approach that respects, in some extent, the requirements of sustainable chemistry. In this context, we report, here