7255-96-1

Usage

Uses

Used in Organic Synthesis:
(3-hydroxybenzylidene)propanedinitrile is used as a chemical intermediate for the synthesis of various organic compounds.
Used in Pharmaceutical and Biological Research:
(3-hydroxybenzylidene)propanedinitrile is used as a research compound for studying its antimicrobial, antifungal, and anticancer properties.
Used in Drug Development:
(3-hydroxybenzylidene)propanedinitrile is being investigated for its potential use in the development of new drugs and therapeutics.

Upstream product

• 100-83-4 meta-hydroxybenzaldehyde 
• 109-77-3 malononitrile 
• 193351-16-5 2-[3-(tert-Butyl-dimethyl-silanyloxy)-benzylidene]-malononitrile 

Downstream Products

• 89607-42-1 6-amino-4-(3-hydroxyphenyl)-3-methyl-1,4-dihydropyrano [2,3-c]pyrazole-5-carbonitrile 
• 220986-31-2 2-amino-4-(3-hydroxy-phenyl)-7-methyl-5-oxo-4H,5H-pyrano[4,3-b]pyran-3-carbonitrile 
• 221178-85-4 6-amino-4-(3-hydroxyphenyl)-3,5-dicyanopyridine-2(1H)-thione 
• 71526-54-0 2-(3-hydroxybenzyl)malononitrile 
• 315248-76-1 ethyl 6-amino-5-cyano-4-(3-hydroxyphenyl)-2-methyl-4H-pyran-3-carboxylate 
• 300701-85-3 2-amino-4-(3-hydroxyphenyl)-7,7-dimethyl-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile 
• 1285689-65-7 3-[(3,5-diamino-1H-pyrazol-4-yl)methyl]phenol 
• 1418009-57-0 6-amino-1-((2-chloro-8-methylquinolin-3-yl)methyleneamino)-4-(3-hydroxyphenyl)-2-oxo-1,2-dihydropyridine-3,5-carbonitrile 
• 333341-17-6 2-amino-4-(3-hydroxyphenyl)-5-oxo-4H,5H-dihydropyrano[3,2-c]chromene-3-carbonitrile 
• 709617-52-7 2-amino-4-(3-hydroxyphenyl)-4H-naphtho[1,2-b]pyran-3-carbonitrile 
• 365517-22-2 7-amino-5-(3-hydroxyphenyl)-2,4-dioxo-1,3,4,5-tetrahydro-2H-pyrano[2,3-d]pyrimidine-6-carbonitrile 
• 309927-00-2 6-amino-2,4-dihydro-4-(3-hydroxyphenyl)-3-methylpyrano[2,3-c]pyrazole-5-carbonitrile 
• 1846-18-0 2-[2,2-dimethyl-1-phenylpropyl]propanedinitrile 

Relevant academic research and scientific papers

Application of structurally enhanced magnetite cored polyamidoamine dendrimer for knoevenagel condensation

In this paper, the synthesis of magnetic cored amino group terminated dendrimer (Fe3O4@SiO2@PAMAM-G2) through covalent bonding was described. This catalyst was characterized by FT-IR, XRD, FE-SEM, TEM, and TGA d

Development of an efficient, one-pot, multicomponent protocol for synthesis of 8-hydroxy-4-phenyl-1,2-dihydroquinoline derivatives

A one-pot quick and efficient multicomponent reaction has been developed for the synthesis of a new series of functionalized 8-hydroxy-4-phenyl-1,2-dihydroquinoline derivatives using 30 mol% ammonium acetate in ethanol as solvent. This economical protocol

Discovery of Highly Potent Adenosine A1Receptor Agonists: Targeting Positron Emission Tomography Probes

Adenosine receptor (AR) radiotracers for positron emission tomography (PET) have provided knowledge on the in vivo biodistribution of ARs in the central nervous system (CNS), which is of therapeutic interest for various neuropsychiatric disorders. Additio

Supramolecular polymeric aggregation behavior and its impact on catalytic properties of imidazolium based hydrophilic ionic liquids

Ionic Liquids (ILs) self-assemble to form supramolecular polymeric clusters/aggregates. The aggregation behavior of ILs influences its activity in the organic synthesis. However, the precise role of ILs in organic reactions is still unknown. It is, therefore, important to comprehend the supramolecular polymeric aggregation behavior of ILs. We are exploring the supramolecular polymeric aggregation behavior of ILs using Electrospray Ionization Mass Spectrometry (ESI-MS). We have synthesized four hydrophilic ILs (1–4) and investigated their aggregation behavior and its impact on catalytic activity in Carbon-Carbon bond formation (Knoevenagel and Claisen-Schmidt condensation). Here, we show that the aggregation behavior of ILs depends on the type and nature of cation and anion. ESI-MS (?ve) spectra reveals two different type of aggregation i.e. [CnAn+1]? & [A2 + H+]?. We have found that catalytic activity increases with increased [CnAn+1]? supramolecular aggregation. Consequently, highest yield of products obtained in ILs which show decreased anion-anion aggregation [A2 + H+]? abundance in ESI-MS. We anticipate our results to be a starting point for the establishment of desired ILs for organic synthesis.

A facile microwave-assisted Knoevenagel condensation of various aldehydes and ketones using amine-functionalized metal organic frameworks

An amine-functionalized metal organic framework (MOF) was used as highly efficient and recyclable heterogeneous catalyst for Knoevenagel condensation of various aromatic aldehydes and ketones in ethanol. The catalytic efficiency was demonstrated by the hi

Structure-induced Lewis-base Ga4B2O9 and its superior performance in Knoevenagel condensation reaction

Solid Lewis-base catalysis is important in the production of fine chemicals. A Lewis-base Ga4B2O9 was synthesized by high temperature solid state reactions. It exhibited a high yield (90 %) and a high stability in Knoevena

Reaction kinetics investigation of Malononitrile with substituted benzaldehydes in aqueous solutions of ethaline as deep eutectic solvent

Due to increasing demands for ecofriendly processes within the framework of green chemistry, and having shown substantial properties, especially in terms of toxicity, biodegradability, cost, and ease of preparation under ambient conditions, deep eutectic

Synthesis, in vitro and in silico screening of 2-amino-4-aryl-6-(phenylthio) pyridine-3,5-dicarbonitriles as novel α-glucosidase inhibitors

Inhibition of α-glucosidase enzyme is of prime importance for the treatment of diabetes mellitus (DM). Apart of many organic scaffolds, pyridine based compounds have previously been reported for wide range of bioactivities. The current study reports a series of pyridine based synthetic analogues for their α-glucosidase inhibitory potential assessed by in vitro, kinetics and in silico studies. For this purpose, 2-amino-4-aryl-6-(phenylthio)pyridine-3,5-dicarbonitriles 1–28 were synthesized and subjected to in vitro screening. Several analogs, including 1–3, 7, 9, 11–14, and 16 showed many folds increased inhibitory potential in comparison to the standard acarbose (IC50 = 750 ± 10 μM). Interestingly, compound 7 (IC50 = 55.6 ± 0.3 μM) exhibited thirteen-folds greater inhibition strength than the standard acarbose. Kinetic studies on most potent molecule 7 revealed a competitive type inhibitory mechanism. In silico studies have been performed to examine the binding mode of ligand (compound 7) with the active site residues of α-glucosidase enzyme.

A multifunctional triazine-based nanoporous polymer as a versatile organocatalyst for CO2 utilization and C-C bond formation

A triazine-based nanoporous multifunctional polymer with a SABET of 304 m2 g-1 has shown versatile catalytic activity in the conversion of CO2 to cyclic carbonates at 4 bar with almost 100% yield and selectivity, and in the conversion of CO2 to methanol and methane electrochemically. Additionally, it also catalyzes C-C bond formation via the Knoevenagel reaction.