31003-24-4

Upstream product

• 1132-38-3 N-cyclohexylidenebenzenamine 
• 868-85-9 Dimethyl phosphite 
• 108-94-1 cyclohexanone 
• 62-53-3 aniline 
• 149-73-5 trimethyl orthoformate 
• 121-45-9 phosphorous acid trimethyl ester 
• 96-36-6 methyl phosphite 

Relevant academic research and scientific papers

Formic acid catalyzed one-pot synthesis of α-aminophosphonates: an efficient, inexpensive and environmental friendly organocatalyst

Abstract: Aqueous formic acid is used for the synthesis of α-aminophosphonates through Kabachnik–Fields reaction applying aromatic amine, phosphite, and carbonyl compounds. Using formic acid as an efficient and low-cost organocatalyst provides environmental friendly, high yields, low reaction time and mild reaction condition. The isolated products were analyzed by IR, NMR, and mass techniques. Graphical abstract: [Figure not available: see fulltext.].

Organocatalytic synthesis of α-aminophosphonates using o-benzenedisul fonimide as a recyclable bronsted acid catalyst

Background: One-Pot three component preparation of α-aminophosphonates in the presence of o-benzenedisulfonimide as efficient acidic organocatalyst has been described. The catalyst can be recovered for further reactions and reused without any loss of efficiency. Methods: A very simple protocol was followed in the reaction process. Initially, we attempted a three component coupling of benzaldehyde with aniline and trimethylphosphite using o-benzenedisulfonimide (5 mol%). The reaction proceeded smoothly at r.t under solvent free conditions and the desired product. Results: The reactions worked well with almost all the aldehydes, heteroaryl aldehydes and ketones; at the end of the reaction, the product could be separated by usual work up. Finally, the water tolerant catalyst may be recycled from water, because of its good solubility in water. Conclusion: The catalyst is a safe, nonvolatile, and noncorrosive Bronsted acid; it is readily recovered at the end of the reactions simply by evaporating the aqueous washings. The products are generally obtained in good yields and short time under simple and mild reaction conditions.

Highly efficient solvent free synthesis of α-aminophosphonates catalyzed by recyclable nano-magnetic sulfated zirconia (Fe3O4@ZrO2/SO42-)

In this project, nano-magnetic sulfated zirconia Fe3O4@ZrO2/SO42- was prepared and characterized using various instrumental methods. Sulfated zirconia supported on magnetic nanoparticles can act as a well-organized nanocatalyst and can be easily separated from the reaction mixture using an external magnetic field. Nano-Fe3O4@ZrO2/SO42- is a heterogeneous acidic catalyst and has particular advantages such as a facile synthesis procedure, high activity, easy separation and reusability. It was applied as an efficient nanocatalyst in the synthesis of α-aminophosphonate derivatives in the Kabachnik-Fields reaction. This synthetic method has several advantages including high yields, short reaction times, easy workup and environmentally benign reaction conditions.

Graphene Oxide as Recyclable Catalyst for One-Pot Synthesis of α-Aminophosphonates

We report the synthesis of α-aminophosphonates from aromatic aldehydes, aromatic and aliphatic amines, and trimethylphosphite (Kabachnik-Fields reaction) using a "carbocatalyst," graphene oxide, at room temperature with excellent yield and recyclability. Enhanced catalytic activity of graphene oxide as compared to other catalysts studied is possibly due to the presence of carboxylic acid and hydroxyl groups. GRAPHICAL ABSTRACT.

Aminophosphonates as novel anti-leishmanial chemotypes: Synthesis, biological evaluation, and CoMFA studies

A series of twenty six structurally diverse α-aminophosphonates have been synthesized and evaluated for in vitro anti-leishmanial activity and cytotoxicity using the MTT assay. Among them, seven compounds (1-7) exhibited anti-leishmanial potency against t

Pentafluorophenylammonium triflate (PFPAT): A new organocatalyst for the one-pot three-component synthesis of α-aminophosphonates

In the presence of a catalytic amount of pentafluorophenylammonium triflate (10 mol %), dimethyl phosphite reacts with imines (generated in situ from aldehydes and amines) to yield the corresponding coupling products in good yield. The organocatalyst is a

A catalyst-free synthesis of α-aminophosphonates in glycerol

A simple and efficient method is described using glycerol as a solvent in the catalyst-free synthesis of α-aminophosphonates in high purity. Products are prepared by the Kabachnik-Fields reaction from amines, phosphites, and carbonyl compounds. The method does not require a toxic catalyst.

Dehydroascorbic acid (DHAA) capped magnetite nanoparticles as an efficient magnetic organocatalyst for the one-pot synthesis of α-aminonitriles and α-aminophosphonates This article is dedicated to memory of Majid Shahriari

A dehydroascorbic acid capped magnetite (DHAA-Fe3O4) catalyst is prepared and used for the one-pot synthesis of α-aminonitriles and α-aminophosphonates. Different derivatives of these compounds are synthesized in good yields.

P-Dodecylbenzenesulfonic acid: A highly efficient catalyst for one-pot synthesis of α-aminophosphonates in aqueous media

A highly efficient one-pot three-component reaction of aldehydes or ketones, amines, and trimethyl or triethyl phosphite catalyzed by p-dodecylbenzensulfonic acid is developed for the synthesis of α-aminophosphonates at room temperature in water.

Superparamagnetic magnesium ferrite nanoparticles: A magnetically reusable and clean heterogeneous catalyst

A highly efficient magnetically recoverable nano-catalyst was fabricated. The material synthesized has been fully characterized by vibrating sample magnetometry (VSM), X-ray powder diffraction, scanning and transmission electron microscopy, FT-IR, and the