31009-04-8

Usage

Uses

Used in Pharmaceutical Synthesis:
7-Bromoquinoline-4-carboxylic acid is used as an intermediate in the synthesis of specific pharmaceutical drugs and research chemicals. Its unique chemical structure allows it to be a key component in the development of new medications, contributing to the advancement of medical treatments.
Used in Chemical Research:
In the field of chemical research, 7-Bromoquinoline-4-carboxylic acid serves as a valuable compound for studying the properties and reactions of bromobenzene derivatives. Its use in research helps to expand the understanding of chemical behavior and potentially leads to the discovery of new applications and compounds.
Used in Organic Chemistry:
7-Bromoquinoline-4-carboxylic acid is utilized in organic chemistry as a reagent or building block for the synthesis of various organic compounds. Its presence in organic reactions can lead to the formation of new molecules with potential applications in various industries, including pharmaceuticals, materials science, and agrochemicals.
Used in Medicinal Chemistry:
In medicinal chemistry, 7-Bromoquinoline-4-carboxylic acid is employed as a starting material for the development of new drugs. Its unique structure and reactivity make it a promising candidate for the design of novel therapeutic agents, potentially leading to the creation of more effective and targeted treatments for various diseases.
Used in Drug Discovery:
7-Bromoquinoline-4-carboxylic acid plays a role in drug discovery processes, where it is used to explore its potential as a lead compound for the development of new pharmaceuticals. Its chemical properties and interactions with biological targets can provide valuable insights into its therapeutic potential and guide the optimization of drug candidates.
Used in Chemical Education:
In the context of chemical education, 7-Bromoquinoline-4-carboxylic acid can be used as a teaching aid to illustrate the principles of organic chemistry, particularly in the areas of aromatic substitution and the synthesis of complex molecules. Its use in educational settings helps to deepen students' understanding of chemical concepts and their applications in real-world scenarios.

Upstream product

• 6326-79-0 6-bromoisatin 
• 113-24-6 sodium pyruvate 
• 52415-29-9 6-bromo-1H-indole 
• 1219834-21-5 7-bromoquinoline-2,4-dicarboxylic acid 

Downstream Products

• 220844-76-8 methyl 7-bromo-4-quinolinecarboxylate 
• 1474034-00-8 7-(phenylamino)quinoline-4-carboxylic acid 

Relevant academic research and scientific papers

Quinoline formamide compound as well as preparation method and application thereof

The invention discloses quinoline formamide compounds as well as a preparation method and application thereof. Specifically, the invention relates to a compound represented by a formula (I) as shown in the specification or a tautomer, a meso-racemate, a r

Synthesis and biological evaluation of novel 2-oxo-1,2-dihydroquinoline-4-carboxamide derivatives for the treatment of esophageal squamous cell carcinoma

No new and effective treatments have been approved for the treatment of esophageal squamous cell carcinoma (ESCC) in the past decade. Cisplatin and 5-fluoruracil are the most commonly used drugs for this disease. In order to develop a new class of drugs effective in our ESCC phenotypic screens, we began a systematic approach to generate novel compounds based on the 2-oxo-1,2-dihydroquinoline-4-carboxamide fragment. Herein, we report on the synthesis and initial assessment of 55 new analogues in two ESCC cell lines. Some of the active analogues with IC50 values around 10 μM were tested in three additional cell lines. Our structure-activity relationships revealed remarkable alterations in the anti proliferative activities upon modest chemical modifications and autophagy modulation is a suggested mechanism of action.

NOVEL FAP INHIBITORS

The present invention relates to novel inhibitors having high selectivity and specificity for FAP (fibroblast activation protein). Said inhibitors are useful as a human and/or veterinary medicine, in particular for the treatment and/or prevention of FAP-related disorders such as but not limited to proliferative disorders.

Selective inhibitors of fibroblast activation protein (FAP) with a (4-quinolinoyl)-glycyl-2-cyanopyrrolidine scaffold

Fibroblast activation protein (FAP) is a serine protease that is generally accepted to play an important role in tumor growth and other diseases involving tissue remodeling. Currently there are no FAP inhibitors with reported selectivity toward both the closely related dipeptidyl peptidases (DPPs) and prolyl oligopeptidase (PREP). We present the discovery of a new class of FAP inhibitors with a N-(4-quinolinoyl)-Gly-(2-cyanopyrrolidine) scaffold. We have explored the effects of substituting the quinoline ring and varying the position of its sp2 hybridized nitrogen atom. The most promising inhibitors combined low nanomolar FAP inhibition and high selectivity indices (>10 3) with respect to both the DPPs and PREP. Preliminary experiments on a representative inhibitor demonstrate that plasma stability, kinetic solubility, and log D of this class of compounds can be expected to be satisfactory.

NOVEL FAP INHIBITORS

The present invention relates to novel inhibitors having high selectivity and specificity for FAP (fibroblast activation protein). Said inhibitors are useful as a human and/or veterinary medicine, in particular for the treatment and/or prevention of FAP-related disorders such as but not limited to proliferative disorders.

Facile and efficient synthesis of quinoline-4-carboxylic acids under microwave irradiation

A facile and efficient method for the preparation of 2-non-substituted quinoline-4-carboxylic acids is described via the Pfitzinger reaction of isatins with sodium pyruvate following consequent decarboxylation under microwave irradiation.