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8-Fluoro-4-hydroxy-2-(trifluoromethyl)quinoline is a synthetic chemical compound belonging to the fluoroquinolone class of antibiotics. It features a quinoline ring with a fluorine atom, a hydroxyl group, and a trifluoromethyl group attached. These chemical characteristics endow it with potent antimicrobial and antibacterial properties, which are instrumental in combating a range of bacterial infections. Its distinctive structure and attributes render it a significant asset in the advancement of antibiotic development and pharmaceutical research.

31009-31-1

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31009-31-1 Usage

Uses

Used in Pharmaceutical Industry:
8-Fluoro-4-hydroxy-2-(trifluoromethyl)quinoline is used as an antimicrobial agent for its effectiveness in treating various bacterial infections. Its unique chemical structure allows it to target and inhibit essential bacterial processes, thereby disrupting their growth and survival.
Used in Antibiotic Development:
8-FLUORO-4-HYDROXY-2-(TRIFLUOROMETHYL)QUINOLINE serves as a valuable precursor in the development of new antibiotics. Its fluoroquinolone nature provides a foundation for the creation of novel antimicrobial agents that can address the growing challenge of antibiotic resistance.
Used in Pharmacological Research:
8-Fluoro-4-hydroxy-2-(trifluoromethyl)quinoline is utilized in research settings to study the mechanisms of action of fluoroquinolone antibiotics. Understanding these mechanisms can lead to the discovery of new therapeutic targets and the improvement of existing treatments for bacterial infections.

Check Digit Verification of cas no

The CAS Registry Mumber 31009-31-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,1,0,0 and 9 respectively; the second part has 2 digits, 3 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 31009-31:
(7*3)+(6*1)+(5*0)+(4*0)+(3*9)+(2*3)+(1*1)=61
61 % 10 = 1
So 31009-31-1 is a valid CAS Registry Number.
InChI:InChI=1/C10H5F4NO/c11-6-3-1-2-5-7(16)4-8(10(12,13)14)15-9(5)6/h1-4H,(H,15,16)

31009-31-1 Well-known Company Product Price

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  • Alfa Aesar

  • (A19696)  8-Fluoro-4-hydroxy-2-(trifluoromethyl)quinoline, 97%   

  • 31009-31-1

  • 1g

  • 995.0CNY

  • Detail

  • Alfa Aesar

  • (A19696)  8-Fluoro-4-hydroxy-2-(trifluoromethyl)quinoline, 97%   

  • 31009-31-1

  • 5g

  • 3983.0CNY

  • Detail

31009-31-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name 8-fluoro-2-(trifluoromethyl)-1H-quinolin-4-one

1.2 Other means of identification

Product number -
Other names 8-Fluor-2-trifluormethylchinolin-4-ol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:31009-31-1 SDS

31009-31-1Downstream Products

31009-31-1Relevant academic research and scientific papers

Selective and efficient structural elaboration of 2-(trifluoromethyl)quinolinones

Marull, Marc,Schlosser, Manfred

, p. 1576 - 1588 (2007/10/03)

The acid-catalyzed cyclization-condensation between anilines and ethyl 4,4,4-trifluoroacetoacetate affords 1,4-dihydro-2-trifluoromethyl-4H-4-quinolinones (1), which can easily be converted into 4-bromo-2-(trifluoromethyl)quinolines. These undergo halogen/metal exchange, generating 2-trifluoromethyl-4-quinolyllithiums, when treated with butyllithium, and hydrogen/metal exchange, generating 4-bromo-2-trifluoromethyl-3-quinolyllithiums, when treated with lithium diisopropylamide. Trapping of the latter intermediates provides 3-functionalized products that may be further elaborated by electrophilic substitution of the bromine atom. A few unexpected findings resulted from these investigations, the most noteworthy being an unprecedented buttressing effect and a counterintuitive halogen reactivity. ( Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003).

PROLINE DERIVATIVES AND USE THEREOF AS DRUGS

-

, (2008/06/13)

The present invention aims at providing compounds having therapeutic effects due to a DPP-IV inhibitory action, and satisfactory as pharmaceutical products. The present inventors have found that derivatives having a substituent introduced into the γ-position of proline represented by the formula (I) wherein each symbol is as defined in the specification, have a potent DPP-IV inhibitory activity, and completed the present invention by increasing the stability.

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