31009-31-1

Basic information

• Product Name: 8-FLUORO-4-HYDROXY-2-(TRIFLUOROMETHYL)QUINOLINE
• Synonyms: BUTTPARK 91\04-30;8-FLUORO-4-HYDROXY-2-(TRIFLUOROMETHYL)QUINOLINE;8-FLUORO-2-(TRIFLUOROMETHYL)QUINOLIN-4-OL;8-Fluoro-4-hydroxy-2-(trifluoromethyl)quinoline 97%;8-Fluoro-4-hydroxy-2-(trifluoromethyl)quinoline97%;8-Fluoro-4-hydro-2-(trifluoromethyl)quinoline
• CAS NO: 31009-31-1
• Molecular Formula: C10H5F4NO
• Molecular Weight: 231.15
• Mol File: 31009-31-1.mol

Chemical Properties

• Melting Point: 111 °C
• Boiling Point: 219.957 °C at 760 mmHg
• Flash Point: 86.827 °C
• Appearance: /
• Density: 1.469 g/cm³
• Vapor Pressure: 0.116mmHg at 25°C
• Refractive Index: 1.5
• PKA: 6.40±0.40(Predicted)
• CAS DataBase Reference: 8-FLUORO-4-HYDROXY-2-(TRIFLUOROMETHYL)QUINOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 8-FLUORO-4-HYDROXY-2-(TRIFLUOROMETHYL)QUINOLINE(31009-31-1)
• EPA Substance Registry System: 8-FLUORO-4-HYDROXY-2-(TRIFLUOROMETHYL)QUINOLINE(31009-31-1)

Safety Data

• Hazard Codes: Xi,T
• Statements: 36/37/38-25
• Safety Statements: 26-36/37/39-37/39-45
• Hazardous Substances Data: 31009-31-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
8-Fluoro-4-hydroxy-2-(trifluoromethyl)quinoline is used as an antimicrobial agent for its effectiveness in treating various bacterial infections. Its unique chemical structure allows it to target and inhibit essential bacterial processes, thereby disrupting their growth and survival.
Used in Antibiotic Development:
8-FLUORO-4-HYDROXY-2-(TRIFLUOROMETHYL)QUINOLINE serves as a valuable precursor in the development of new antibiotics. Its fluoroquinolone nature provides a foundation for the creation of novel antimicrobial agents that can address the growing challenge of antibiotic resistance.
Used in Pharmacological Research:
8-Fluoro-4-hydroxy-2-(trifluoromethyl)quinoline is utilized in research settings to study the mechanisms of action of fluoroquinolone antibiotics. Understanding these mechanisms can lead to the discovery of new therapeutic targets and the improvement of existing treatments for bacterial infections.

InChI:InChI=1/C10H5F4NO/c11-6-3-1-2-5-7(16)4-8(10(12,13)14)15-9(5)6/h1-4H,(H,15,16)

Upstream product

• 348-54-9 2-Fluoroaniline 
• 372-31-6 ethyl 4,4,4-trifluoroacetoacetate 

Relevant articles and documents

Selective and efficient structural elaboration of 2-(trifluoromethyl)quinolinones

The acid-catalyzed cyclization-condensation between anilines and ethyl 4,4,4-trifluoroacetoacetate affords 1,4-dihydro-2-trifluoromethyl-4H-4-quinolinones (1), which can easily be converted into 4-bromo-2-(trifluoromethyl)quinolines. These undergo halogen/metal exchange, generating 2-trifluoromethyl-4-quinolyllithiums, when treated with butyllithium, and hydrogen/metal exchange, generating 4-bromo-2-trifluoromethyl-3-quinolyllithiums, when treated with lithium diisopropylamide. Trapping of the latter intermediates provides 3-functionalized products that may be further elaborated by electrophilic substitution of the bromine atom. A few unexpected findings resulted from these investigations, the most noteworthy being an unprecedented buttressing effect and a counterintuitive halogen reactivity. ( Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003).

PROLINE DERIVATIVES AND USE THEREOF AS DRUGS

The present invention aims at providing compounds having therapeutic effects due to a DPP-IV inhibitory action, and satisfactory as pharmaceutical products. The present inventors have found that derivatives having a substituent introduced into the γ-position of proline represented by the formula (I) wherein each symbol is as defined in the specification, have a potent DPP-IV inhibitory activity, and completed the present invention by increasing the stability.