3101-09-5

Usage

Physical state

Colorless liquid, meaning it has no color and flows like a liquid at room temperature.

Odor

Sweet, fruity odor, describing the pleasant and fruity smell of the compound.

Application in perfumery and flavoring

Utilized in the manufacturing of perfumes and flavors due to its pleasant aroma, enhancing the scent and taste of products.

Pharmaceutical industry use

Serves as an intermediate in the synthesis of various drugs and as a reagent in organic chemistry, playing a crucial role in the development of medications.

Safety precautions

Must be handled with caution, as it can be harmful if inhaled, ingested, or in contact with the skin, posing potential health risks.

Upstream product

• 2979-85-3 4-ethyl-hexanoyl chloride 
• 71-43-2 benzene 
• 97-95-0 2-ethyl-1-butanol 
• 98-86-2 acetophenone 
• 936-59-4 3-chloropropiophenone 

Relevant academic research and scientific papers

Iron-Catalyzed, Iminyl Radical-Triggered Cascade 1,5-Hydrogen Atom Transfer/(5+2) or (5+1) Annulation: Oxime as a Five-Atom Assembling Unit

By integration of iminyl radical-triggered 1,5-hydrogen atom transfer and (5+2) or (5+1) annulation processes, a series of structurally novel and interesting azepine and spiro-tetrahydropyridine derivatives have been successfully prepared in moderate to good yields. This method utilizes FeCl2 as the catalyst and readily available oximes as five-atom units, while showcasing broad substrate scope and good functional group compatibility. The annulation products can be easily converted into many valuable compounds. Moreover, DFT calculation studies are performed to provide some insights into the possible reaction mechanisms for the (5+2) and (5+1) annulations.

Mn-Enabled Radical-Based Alkyl-Alkyl Cross-Coupling Reaction from 4-Alkyl-1,4-dihydropyridines

Highly efficient alkylation of β-chloro ketones and their derivatives was achieved by means of domino dehydrochlorination/Mn-enabled radical-based alkyl-alkyl cross-coupling reaction. In situ-generated α,β-unsaturated ketones and their analogues were identified as the reaction intermediates. Known bioactive compounds, such as melperone and azaperone, could be easily prepared from β-chloropropiophenone in two steps.

An Efficient α-alkylation of aromatic ketones with primary alcohols catalyzed by [cp*ircl2]2 without solvent

Aromatic ketones are directly alkylated at α position with primary alcohols at 110°C in the presence of catalytic amount of KOH and [Cp*IrCl2]2 (Cp=pentamethylcyclopentadienyl) catalyst. The reaction is carried out in the absence of any solvent or additive, which generates only water as the byproduct in theory. It is very efficient and generally completed in 10 min in good isolated yields. The reaction is believed to undergo successive hydrogen transfer and cross aldol condensation processes. Copyright