31039-62-0

Basic information

• Product Name: 2,6-Dihydroxy-1,4-naphthoquinone
• Synonyms: 2,6-Dihydroxy-1,4-naphthoquinone
• CAS NO: 31039-62-0
• Molecular Formula: C₁₀H₆O₄
• Molecular Weight: 190.15
• Mol File: 31039-62-0.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2,6-Dihydroxy-1,4-naphthoquinone(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-Dihydroxy-1,4-naphthoquinone(31039-62-0)
• EPA Substance Registry System: 2,6-Dihydroxy-1,4-naphthoquinone(31039-62-0)

Safety Data

• Hazardous Substances Data: 31039-62-0(Hazardous Substances Data)

Upstream product

• 78758-31-3 2-anilino-6-hydroxy-[1,4]naphthoquinone 
• 671790-49-1 1,2,4,6-tetraacetoxy-naphthalene 
• 581-43-1 2.6-dihydroxynaphthalene 
• 575-44-0 1,6-dihydroxynaphthalene 
• 6223-31-0 6-methoxylawsone 
• 1078-19-9 6-methoxy-3,4-dihydro-1(2H)-naphthalenone 
• 4923-53-9 6-hydroxy-[1,4]naphthoquinone 
• 3470-50-6 6-Hydroxy-1-tetralone 

Relevant articles and documents

Reactivity of potassium superoxide in heterogeneous phase: Oxidation of naphthalenediols and hydroxylated naphthoquinones

Oxidation of dihydroxynaphthalenes by potassium superoxide (KO2) in heterogeneous aprotic media yields mono- or dihydroxynaphthoquinones, depending on the relative position of the hydroxy groups on the naphthalene moiety. The reaction proceeds mainly at the solid-liquid interface and naphthoquinones can be obtained with good yields.

Identification of β-lapachone analogs as novel MALT1 inhibitors to treat an aggressive subtype of diffuse large B-cell lymphoma

The treatment of activated B cell-like DLBCL (ABC-DLBCL) is one of the urgent unmet medical needs because it is the most resistant DLBCL subtype to current therapies eagerly awaiting effective therapeutic strategies. Recently, the paracaspase MALT1 has emerged as a promising therapeutic target for the treatment of ABC-DLBCL. Herein, we report a new class of MALT1 inhibitors developed by high-throughput screening and structure-based drug design. The original hit, 4-amino-1,2-naphthoquinone series inhibited MALT1 activity but suffered from poor cellular activity. The extensive pharmacophore search led to the discovery of structurally similar β-lapachone that is a direct inhibitor of MALT1 and possesses favorable physicochemical properties. Molecular simulation studies suggested the possibility of the formation of a covalent bond between MALT1 and β-lapachone, which was corroborated by experimental wash-out studies. Inspired by this, we explored the structure-activity relationships by incorporating electron-withdrawing substituents at C8 position of β-lapachone. These MALT1 inhibitors exhibited potent antiproliferative activity to OCI-LY3 cell line and inhibited the cleavage of CYLD mediated MALT1.

Method for dyeing keratinous fibres using a monohydroxyindole or dihydroxyindole and a non-oxidizing aromatic carbonyl derivative and dyeing agent

The present invention relates to a method for dyeing keratinous fibers, characterized in that the following are applied to the fibers: a) a composition (A) containing, in a medium appropriate for dyeing, at least one monohydroxyindole or dihydroxyindole, this application being preceded or followed by the application of b) a composition (B) containing, in a medium appropriate for dyeing, at least one aromatic carbonyl derivative chosen from hydroxyacetophenones, hydroxybenzophenones, 2-hydroxy-1,4-benzoquinones, hydroxy-1,4-naphthoquinones,amino-1,4-naphthoquinones,hydroxy-9,10-anthraquinones and amino-9,10-anthraquinones. It also relates to the dyeing agents for carrying it out.