31040-18-3

Usage

Uses

Used in Pharmaceutical Industry:
8-NITRO[1,2,4]TRIAZOLO[1,5-A]PYRIDINE is used as a potential drug candidate for the development of new pharmaceuticals. Its unique chemical structure and properties make it a promising candidate for the treatment of various diseases and conditions.
Used in Organic Synthesis:
8-NITRO[1,2,4]TRIAZOLO[1,5-A]PYRIDINE is used as a building block in the synthesis of other organic compounds. Its versatile chemical structure allows for the creation of a wide range of molecules with diverse applications in various industries.
Used in Research Studies:
8-NITRO[1,2,4]TRIAZOLO[1,5-A]PYRIDINE is used as a subject of research in various scientific studies. Its unique properties and potential applications have made it an interesting compound for researchers to explore and understand its full potential in different fields.

InChI:InChI=1/C6H4N4O2/c11-10(12)5-2-1-3-9-6(5)7-4-8-9/h1-4H

Upstream product

• 15367-16-5 2-Hydrazino-3-nitropyridine 
• 64-18-6 formic acid 

Downstream Products

• 1340879-45-9 N-([1,2,4]triazolo[1,5-a]pyridin-8-yl)-2-(4-methoxyphenyl)acetamide 
• 1569870-48-9 N-(4-methoxyphenethyl)-[1,2,4]triazolo[1,5-a]pyridin-8-amine 
• 1569870-51-4 4-(2-([1,2,4]triazolo[1,5-a]pyridin-8-ylamino)ethyl)phenol 

Relevant academic research and scientific papers

Keeping it small, polar, and non-flat: diversely functionalized building blocks containing the privileged 5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]- and [1,5-a]pyridine cores

Six sets of functionalized building blocks based on 5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine as well as 5,6,7,8-tetrahydro[1,2,4]triazolo[1,5-a]pyridine cores have been prepared. These compounds are non-flat, bicyclic heterocycles that are likely to find utility as privileged motifs for lead-like compound design. One set of building blocks, (5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridin-6-ylmethyl)amines, proved useful as a scaffold for developing compounds that stimulate glucagon-like peptide-1 (GLP-1) secretion and are novel anti-diabetes drug leads.

Design, synthesis, crystallographic studies, and preliminary biological appraisal of new substituted triazolo[4,3-b]pyridazin-8-amine derivatives as tankyrase inhibitors

Searching for selective tankyrases (TNKSs) inhibitors, a new small series of 6,8-disubstituted triazolo[4,3-b]piridazines has been synthesized and characterized biologically. Structure-based optimization of the starting hit compound NNL (3) prompted us to the discovery of 4-(2-(6-methyl-[1,2,4] triazolo[4,3-b]pyridazin-8-ylamino)ethyl)phenol (12), a low nanomolar selective TNKSs inhibitor working as NAD isostere as ascertained by crystallographic analysis. Preliminary biological data candidate this new class of derivatives as a powerful pharmacological tools in the unraveling of TNKS implications in physiopathological conditions.

Synthese et etude physicochimique des 1,2,4-triazolopyridines et des 1,2,4-triazolopyridines

The synthesis of 1,2,4-triazolo and pyridines 7, 8 was achieved by cyclization of 2-hydrazino-3-nitropyridine 3a with formic acid.The 4,5,6,7-tetrahydro-1,2,4-triazolopyridine 13 and 8-amino-1,2,4-triazolopyridine 9 were obtained by catalytic hydrogenation.The reduction of triazolopyridine 8 using stannous chloride led to the intermediate compound 10 which with acetic anhydride afforded 8-acetylamino-5-chloro-1,2,4-triazolopyridine 10a.The structure of the derivatives was determined by 1H-nmr (DMSO-d6).