310442-33-2

Basic information

• Product Name: Pyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid, 4-[(3-hydroxy-4-methylphenyl)amino]-5-methyl-
• CAS NO: 310442-33-2
• Molecular Formula: C15H14N4O3
• Molecular Weight: 298.301
• Mol File: 310442-33-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Pyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid, 4-[(3-hydroxy-4-methylphenyl)amino]-5-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Pyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid, 4-[(3-hydroxy-4-methylphenyl)amino]-5-methyl-(310442-33-2)
• EPA Substance Registry System: Pyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid, 4-[(3-hydroxy-4-methylphenyl)amino]-5-methyl-(310442-33-2)

Safety Data

• Hazardous Substances Data: 310442-33-2(Hazardous Substances Data)

Upstream product

• 310442-40-1 methyl 4-chloro-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxylate 
• 310431-29-9 5-methyl-4-oxo-3,4-dihydro-pyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid methyl ester 
• 3780-42-5 dimethyl 3-methyl-1H-pyrrole-2,4-dicarboxylate 
• 40318-15-8 methyl 4-methyl-1H-pyrrole-3-carboxylate 
• 310431-26-6 dimethyl 1-amino-3-methyl-1H-pyrrole-2,4-dicarboxylate 
• 310442-32-1 4-[(3-Hydroxy-4-methylphenyl)amino]-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid methyl ester 

Relevant articles and documents

Synthesis and SAR of 4-(3-hydroxyphenylamino)pyrrolo[2,1-f][1,2,4]triazine based VEGFR-2 kinase inhibitors

A versatile synthesis of the suitably functionalized pyrrolo[2,1-f][1,2,4] triazine nucleus is described. SAR at the C-5 and C-6 positions of the 4-(3-hydroxy-4-methylphenylamino)pyrrolo[2,1-f][1,2,4]triazine template led to compounds with good in vitro potency against VEGFR-2 kinase. Glucuronidation of the phenol group is mitigated by incorporation of a basic amino group on the C-6 side chain of the pyrrolotriazine nucleus.