310444-76-9Relevant academic research and scientific papers
Pyrrolotriazine inhibitors of kinases
-
Page/Page column 68, (2008/06/13)
The present invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The formula I compounds inhibit the tyrosine kinase activity of growth factor receptors such as VEGFR-2, FGFR-1, PDGFR, HER-1, HER-2, thereby making them useful as anti-cancer agents. The formula I compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.
Methods of treating p38 kinase-associated conditions and pyrrolotriazine compounds useful as kinase inhibitors
-
, (2008/06/13)
Methods of treating one or more conditions associated with p38 kinase activity are disclosed comprising administering to a patient in need thereof at least one compound having the formula (I): 1or a pharmaceutically acceptable salt, prodrug, or solvate thereof, wherein R3 is hydrogen, methyl, perfluoromethyl, methoxy, halogen, cyano, or NH2, preferably methyl, and X, R1 through R6, and Z are as described in the specification. Advantageously the groups —ZR4R5 taken together comprise an —NH-substituted aryl.
3,3′- and 4,4′-dimethoxy-2,2′-bipyrroles: Highly electron-rich model compounds for polypyrrole formation
Merz, Andreas,Anikin, Sergiy,Lieser, Bernd,Heinze, Juergen,John, Hermann
, p. 449 - 455 (2007/10/03)
3,3′-Dimethoxy-2,2′-bipyrrole (1) and 4,4′- dimethoxy-2,2′-bipyrrole (2) were obtained in short sequences and good yields from N-benzyl-3-hydroxypyrrole-2,4-dicarboxylic acid. The key intermediate leading to 1 is an N-benzyl-3-methoxypyrrole, which is dim
