65171-75-7

Upstream product

• 65209-69-0 [[(2-Ethoxy-2-oxoethyl)(phenylmethyl)amino]methylene]propanedioic Acid Diethyl Ester 

Downstream Products

• 310444-76-9 diethyl 1-benzyl-3-methoxypyrrole-2,4-dicarboxylate 
• 525575-27-3 diethyl 1-benzyl-2-bromo-4-hydroxypyrrole-3,5-dicarboxylate 
• 65171-83-7 1-benzyl-3-hydroxy-1H-pyrrole-2,4-dicarboxylic acid 2-ethyl ester 
• 837407-16-6 1-benzyl-4-(1-benzyl-piperidin-4-ylcarbamoyl)-3-hydroxy-1H-pyrrole-2-carboxylic acid ethyl ester 
• 525575-29-5 tetraethyl 1,1'-dibenzyl-4,4'-dimethoxy-2,2'-bipyrrole-3,3',5,5'-tetracarboxylate 
• 525575-30-8 1,1'-dibenzyl-4,4'-dimethoxy-2,2'-bipyrrole-3,3',5,5'-tetracarboxylic acid 
• 525575-28-4 diethyl 1-benzyl-2-bromo-4-methoxypyrrole-3,5-dicarboxylate 
• 525575-31-9 1,1'-dibenzyl-4,4'-dimethoxy-2,2'-bipyrrole 
• 525575-24-0 1,1'-dibenzyl-3,3'-dimethoxy-2,2'-bipyrrole 
• 525575-22-8 1-benzyl-3-methoxypyrrole-2,4-dicarboxylic acid 
• 90968-45-9 1-Benzyl-3-methoxypyrrole 

Relevant academic research and scientific papers

Pyrrolotriazine inhibitors of kinases

The present invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The formula I compounds inhibit the tyrosine kinase activity of growth factor receptors such as VEGFR-2, FGFR-1, PDGFR, HER-1, HER-2, thereby making them useful as anti-cancer agents. The formula I compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.

Methods of treating p38 kinase-associated conditions and pyrrolotriazine compounds useful as kinase inhibitors

Methods of treating one or more conditions associated with p38 kinase activity are disclosed comprising administering to a patient in need thereof at least one compound having the formula (I): 1or a pharmaceutically acceptable salt, prodrug, or solvate thereof, wherein R3 is hydrogen, methyl, perfluoromethyl, methoxy, halogen, cyano, or NH2, preferably methyl, and X, R1 through R6, and Z are as described in the specification. Advantageously the groups —ZR4R5 taken together comprise an —NH-substituted aryl.