310444-84-9

Basic information

• Product Name: Pyrrolo[2,1-f][1,2,4]triazin-6-ol, 5-methyl-4-phenoxy-
• CAS NO: 310444-84-9
• Molecular Formula: C13H11N3O2
• Molecular Weight: 241.24500
• Mol File: 310444-84-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Pyrrolo[2,1-f][1,2,4]triazin-6-ol, 5-methyl-4-phenoxy-(CAS DataBase Reference)
• NIST Chemistry Reference: Pyrrolo[2,1-f][1,2,4]triazin-6-ol, 5-methyl-4-phenoxy-(310444-84-9)
• EPA Substance Registry System: Pyrrolo[2,1-f][1,2,4]triazin-6-ol, 5-methyl-4-phenoxy-(310444-84-9)

Safety Data

• Hazardous Substances Data: 310444-84-9(Hazardous Substances Data)

Upstream product

• 310444-83-8 4-phenoxy-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxaldehyde 
• 1363380-63-5 C₁₆H₁₅N₃O₃ 

Downstream Products

• 649736-28-7 6-(benzyloxy)-4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[2,1-f][1,2,4]triazine 
• 649735-46-6 Brivanib 
• 649735-41-1 4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-ol 
• 649736-26-5 6-(benzyloxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-4-ol 
• 649736-27-6 6-(benzyloxy)-4-chloro-5-methylpyrrolo[2,1-f][1,2,4]triazine 
• 886585-68-8 6-(benzyloxy)-5-methyl-4-phenoxypyrrolo[2,1-f][1,2,4]triazine 

Relevant articles and documents

Commercial synthesis of a pyrrolotriazine-fluoroindole intermediate to brivanib alaninate: Process development directed toward impurity control

The development of a practical, commercial process for the preparation of 4-fluoro-2-methyl-indol-5-ol and its subsequent coupling with a pyrrolotriazine to form an advanced intermediate of the oncology therapy brivanib alaninate is described. A key aspect is the multikilogram-scale preparation of the fluoroindole intermediate from trifluoronitrobenzene and the subsequent coupling while achieving impurity minimalization. As brivanib alaninate is a high-dose drug, the synthesis of highquality API with low levels of impurities is critical.