649736-26-5

Basic information

• Product Name: 6-(Benzyloxy)-5-Methylpyr...
• Synonyms: 6-(Benzyloxy)-5-Methylpyr...;6-(Benzyloxy)-5-Methylpyrrolo[1,2-f][1,2,4]triazin-4(3H)-one;6-(benzyloxy)-5-methyl-3H,4H-pyrrolo[2,1-f][1,2,4]triazin-4-one
• CAS NO: 649736-26-5
• Molecular Formula: C₁₄H₁₃N₃O₂
• Molecular Weight: 255.28
• Mol File: 649736-26-5.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 6-(Benzyloxy)-5-Methylpyr...(CAS DataBase Reference)
• NIST Chemistry Reference: 6-(Benzyloxy)-5-Methylpyr...(649736-26-5)
• EPA Substance Registry System: 6-(Benzyloxy)-5-Methylpyr...(649736-26-5)

Safety Data

• Hazardous Substances Data: 649736-26-5(Hazardous Substances Data)

Usage

General Description

6-(Benzyloxy)-5-methylpyrimidine is a chemical compound with the molecular formula C13H13N3O. It is a pyrimidine derivative with a benzyl group and a methyl group attached to the pyrimidine ring. 6-(Benzyloxy)-5-Methylpyr... is commonly used in organic synthesis and pharmaceutical research, particularly in the development of new drugs and medications. It has been studied for its potential pharmacological properties, including its antiviral and anticancer activities. Additionally, it serves as a building block for the synthesis of various heterocyclic compounds with diverse biological and pharmaceutical functions. Overall, 6-(benzyloxy)-5-methylpyrimidine is a versatile chemical compound with potential applications in drug discovery and development.

Upstream product

• 64-17-5 ethanol 
• 100-39-0 benzyl bromide 
• 310444-84-9 4-Phenoxy-5-methyl-6-hydroxypyrrolo[2,1-f][1,2,4]triazine 
• 886585-68-8 6-(benzyloxy)-5-methyl-4-phenoxypyrrolo[2,1-f][1,2,4]triazine 

Downstream Products

• 649735-41-1 4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-ol 
• 649735-46-6 Brivanib 
• 649736-28-7 6-(benzyloxy)-4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[2,1-f][1,2,4]triazine 
• 649736-27-6 6-(benzyloxy)-4-chloro-5-methylpyrrolo[2,1-f][1,2,4]triazine 

Relevant articles and documents

Discovery and preclinical studies of (R)-1-(4-(4-fluoro-2-methyl-1H-indol- 5-yloxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy)propan-2-ol (BMS-540215), an in vivo active potent VEGFR-2 inhibitor

A series of substituted 4-(4-fluoro-1H-indol-5-yloxy)pyrrolo-[2.1-f][1,2,4] triazine-based inhibitors of vascular endothelial growth factor receptor-2 kinase is reported. Structure-activity relationship studies revealed that a methyl group at the 5-position and a substituted alkoxy group at the 6-position of the pyrrolo[2,1-f][1,2,4]triazine core gave potent compounds. Biochemical potency, kinase selectivity, and pharmacokinetics of the series were optimized and in vitro safety liabilities were minimized to afford BMS-540215 (12), which demonstrated robust preclinical in vivo activity in human tumor xenograft models. The L-alanine prodrug of 12, BMS-582664 (21), is currently under evaluation in clinical trials for the treatment of solid tumors.