310451-83-3Relevant academic research and scientific papers
Synthesis, crystal structure, and biological activity of diethyl-2-[5-(4-fluorophenyl)-7-(trifluoromethyl)pyrazolo[1,5-a] pyrimidine-3-carboxamido]pentanedioate
Ju, Liu,Ge, Hong-Guang,Lu, Jiu-Fu
, p. 4 - 6 (2015)
The title compound, diethyl-2-[5-(4-fluorophenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamido]pentanedioate (C23H22F4N4O5, Mr = 510.45) was synthesised and structurally characterised by
Synthesis, crystal structure and biological activity of 5-(4-fluorophenyl)-N,Ndimethyl- 7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide
Liu, Ju,Song, Duan-Zheng,Tian, Yan-Qiu,Zhang, Xin-Wei,Bai, Yue-Fei,Wang, Dan
, p. 107 - 109 (2016)
The title compound, 5-(4-fluorophenyl)-N,N-dimethyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide, has been synthesised by condensation of dimethylamine with 5-(4-fluorophenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid. T
Synthesis method of 5-(4-fluorophenyl)-N, N-dimethyl-7-trifluoromethylpyrazol[1, 5-a] pyrimidine-3-amide
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, (2018/02/04)
The invention discloses a synthesis method of 5-(4-fluorophenyl)-N, N-dimethyl-7-trifluoromethylpyrazol[1, 5-a] pyrimidine-3-amide. The synthesis method includes: using arone which is low in cost and easy to obtain as a starting raw material; synthesizing arone and para-trifluoromethyl ethyl acetate into an intermediate-aryl butanedione, adding glacial acetic acid and aminopyrazol, and heating for backflow to generate a target intermediate; hydrolyzing to obtain 5-aryl-7-substitutent pyrazol[1, 5-a] pyrimidine acid, and obtaining a target product through condensation reaction. Through continuous reaction of condensation and cyclization, 5-(4-fluorophenyl)-N, N-dimethyl-7-trifluoromethylpyrazol[1, 5-a] pyrimidine-3-amide is synthesized with high yield. The synthesis method is simple and convenient to operate and high in yield, and the product is easy to purify.
Synthesis method of 5-(4-fluorophenyl)-N-1-(3-hydroxyadamantyl)-7-trifluoromethylpyrazolo[1,5-a]pyrimidyl-3-amide
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, (2016/10/17)
The invention discloses a synthesis method of 5-(4-fluorophenyl)-N-1-(3-hydroxyadamantyl)-7-trifluoromethylpyrazolo[1,5-a]pyrimidyl-3-amide. By using the cheap accessible arone as the initial raw material, the synthesis route comprises the following steps: synthesizing an intermediate aryl butanedione from aryl ketone and ethyl p-trifluoromethylacetate, adding glacial acetic acid and amino pyrazole, and heating under reflux to generate a target intermediate; hydrolyzing to obtain 5-aryl-7-substituted-pyrazolo[1,5-a]pyrimidine acid; and finally, carrying out condensation reaction to obtain the target product. By using the condensation-cyclization two-step continuous reaction, the 5-(4-fluorophenyl)-N-1-(3-hydroxyadamantyl)-7-trifluoromethylpyrazolo[1,5-a]pyrimidyl-3-amide is synthesized at higher yield. The method is simple to operate and higher in yield, and can easily purify the product.
5 - (4-fluoro phenyl) - 7-trifluoromethyl-pyrazolo [1,5-a] pyrimidine-3-carboxylic acid synthesizing method (by machine translation)
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, (2016/10/31)
The present invention discloses the 5 [...] (the 4 [...] phenyl) - 7 the [...] trifluoromethyl-pyrazolo [1,5 the ??a] pyrimidine -3 the method for synthesizing carboxylic acid [...], the method uses the cheap and easily obtained arone as the starting mate
Synthesis method of 5-(4-fluorophenyl)-N-(3-(dimethylamino) propyl)-7-trifluoromethyl pyrazol[1, 5-a] pyrimidine-3-amide
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, (2017/05/27)
The invention discloses a synthesis method of 5-(4-fluorophenyl)-N-(3-(dimethylamino) propyl)-7-trifluoromethyl pyrazol[1, 5-a] pyrimidine-3-amide. The synthesis method includes: using arone which is low in cost and easy to obtain as a starting raw material; synthesizing arone and para-trifluoromethyl ethyl acetate into an intermediate-aryl butanedione, adding glacial acetic acid and aminopyrazol, and heating for backflow to generate a target intermediate; hydrolyzing to obtain 5-aryl-7-substitutent pyrazol[1, 5-a] pyrimidine acid, and obtaining a target product through condensation reaction. Through continuous reaction of condensation and cyclization, 5-(4-fluorophenyl)-N-(3-(dimethylamino) propyl)-7-trifluoromethyl pyrazol[1, 5-a] pyrimidine-3-amide is synthesized with high yield. The synthesis method is simple and convenient to operate and high in yield, and the product is easy to purify.
Synthesis method of 2-(5-(4-fluorophenyl)-7-trifluoromethylpyrazolo[1,5-a]pyrimidine-3-amide)diethyl glutarate
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, (2017/10/14)
The invention discloses a synthesis method of 2-(5-(4-fluorophenyl)-7-trifluoromethylpyrazolo[1,5-a]pyrimidine-3-amide)diethyl glutarate. The method takes aryl ketone which is cheap and easy to obtain as a starting raw material, and a synthesis route comprises the following steps: synthesizing an intermediate aryl butanedione by aryl ketone and p-trifluoromethyl ethyl acetate; adding glacial acetic acid and amino-pyrazole, and heating and reflowing to generate a target intermediate; hydrolyzing to obtain 5-aryl-7-substituent pyrazolo[1,5-a]pyrimidine acid; and finally, carrying out a condensation reaction to obtain a target product. By carrying out condensation and closed-ring two-step continuous reaction, 2-(5-(4-fluorophenyl)-7-trifluoromethylpyrazolo[1,5-a]pyrimidine-3-amide)diethyl glutarate is synthesized at a relatively high yield. The method is simple and convenient to operate, the yield is relatively high, and the product is easy to purify.
Synthesis method of 5-(4-fluorophenyl)-N-morpholinyl-7-trifluoromethylpyrazolo[1,5-a]pyrimidyl-3-amide
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, (2017/10/21)
The invention discloses a synthesis method of 5-(4-fluorophenyl)-N-morpholinyl-7-trifluoromethylpyrazolo[1,5-a]pyrimidyl-3-amide. By using the cheap accessible arone as the initial raw material, the synthesis route comprises the following steps: synthesizing an intermediate aryl butanedione from aryl ketone and ethyl p-trifluoromethylacetate, adding glacial acetic acid and amino pyrazole, and heating under reflux to generate a target intermediate; hydrolyzing to obtain 5-aryl-7-substituted-pyrazolo[1,5-a]pyrimidine acid; and finally, carrying out condensation reaction to obtain the target product. By using the condensation-cyclization two-step continuous reaction, the 5-(4-fluorophenyl)-N-morpholinyl-7-trifluoromethylpyrazolo[1,5-a]pyrimidyl-3-amide is synthesized at higher yield. The method is simple to operate and higher in yield, and can easily purify the product.
Method for synthesizing 5-arylpyrazole [1, 5-alpha] pyrimindine derivatives
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, (2018/02/04)
The invention discloses a method for synthesizing 5-arylpyrazole [1, 5-alpha] pyrimindine derivatives. Inexpensive and easily available arone is used as a starting material. The method includes synthetic paths of synthesizing aryl ketone and phenyl acetic acid ethyl acetate to obtain aryl diacetyl which is an intermediate, adding glacial acetic acid and aminopyrazole into the aryl diacetyl and carrying out heating reflux to generate a target intermediate; hydrolyzing the target intermediate to obtain 5-aryl-7-substituent pyrazole [1, 5-alpha] pyrimindine acid; ultimately carrying out condensation reaction to obtain target products. The method has the advantages that a series of 5-aryl-substituted pyrazole [1, 5-alpha] pyrimindine compounds with high yields can be synthesized via condensation and ring closing two-step continuous reaction; the method is easy and convenient to implement and high in yield, and the products are easy to purify.
5 - (4-fluoro phenyl)-N - (4-chloro-ethyl) - 7-trifluoromethyl-pyrazolo [1,5-a] pyrimidine-3-carboxamide synthesis method (by machine translation)
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, (2018/02/04)
The present invention discloses the 5 [...] (the 4 [...] phenyl)-N - (the 4 [...] paradichlorbenzene ethyl) - 7 the [...] trifluoromethyl-pyrazolo [1,5 the ??a] pyrimidine -3 the method for synthesizing amide of [...], the method uses the cheap and easily obtained arone as the starting material, the synthesis route to ketones with the trifluoromethyl ethyl acetate synthetic intermediate aryl diacetyls, by adding glacial acetic acid and Aminopyrazole, heating to reflux to generate the target intermediate. After hydrolysis of the 5 [...] aryl -7 the substituted pyrazoles and [...] [1, the 5 ??a] pyrimidine acid, the final condensation reaction to obtain the target product. This invention, through condensation, ring two-step continuous reaction, at a high yield of the synthesis of the 5 [...] (the 4 [...] phenyl)-N - (the 4 [...] paradichlorbenzene ethyl) - 7 the [...] trifluoromethyl-pyrazolo [1,5 the ??a] pyrimidine -3 the amide [...]. The method is simple and convenient to operate, the yield is high, the product can be easily purified. (by machine translation)
