31052-95-6

Usage

Uses

Used in Medicinal Chemistry:
[1,2,4]Triazolo[1,5-a]pyridin-8-amine is utilized as a synthetic intermediate for the development of new drugs. Its heterocyclic structure provides a versatile platform for the attachment of various functional groups, enabling the design of pharmaceuticals with targeted therapeutic effects.
Used in Agrochemicals:
In the agrochemical industry, [1,2,4]Triazolo[1,5-a]pyridin-8-amine is employed as a key component in the synthesis of pesticides and other crop protection agents. Its unique chemical properties allow for the creation of compounds that can effectively combat pests and diseases while minimizing environmental impact.
Used in Materials Science:
[1,2,4]Triazolo[1,5-a]pyridin-8-amine also finds applications in materials science, where it is used to develop advanced materials with specific properties. Its heterocyclic structure can contribute to the formation of materials with tailored characteristics, such as improved stability, conductivity, or optical properties, depending on the intended application.

InChI:InChI=1/C6H6N4/c7-5-2-1-3-10-6(5)8-4-9-10/h1-4H,7H2

Upstream product

• 15367-16-5 2-Hydrazino-3-nitropyridine 

Downstream Products

• 1569870-48-9 N-(4-methoxyphenethyl)-[1,2,4]triazolo[1,5-a]pyridin-8-amine 
• 1569870-51-4 4-(2-([1,2,4]triazolo[1,5-a]pyridin-8-ylamino)ethyl)phenol 
• 1340879-45-9 N-([1,2,4]triazolo[1,5-a]pyridin-8-yl)-2-(4-methoxyphenyl)acetamide 

Relevant academic research and scientific papers

Design, synthesis, crystallographic studies, and preliminary biological appraisal of new substituted triazolo[4,3-b]pyridazin-8-amine derivatives as tankyrase inhibitors

Searching for selective tankyrases (TNKSs) inhibitors, a new small series of 6,8-disubstituted triazolo[4,3-b]piridazines has been synthesized and characterized biologically. Structure-based optimization of the starting hit compound NNL (3) prompted us to the discovery of 4-(2-(6-methyl-[1,2,4] triazolo[4,3-b]pyridazin-8-ylamino)ethyl)phenol (12), a low nanomolar selective TNKSs inhibitor working as NAD isostere as ascertained by crystallographic analysis. Preliminary biological data candidate this new class of derivatives as a powerful pharmacological tools in the unraveling of TNKS implications in physiopathological conditions.

Synthese et etude physicochimique des 1,2,4-triazolopyridines et des 1,2,4-triazolopyridines

The synthesis of 1,2,4-triazolo and pyridines 7, 8 was achieved by cyclization of 2-hydrazino-3-nitropyridine 3a with formic acid.The 4,5,6,7-tetrahydro-1,2,4-triazolopyridine 13 and 8-amino-1,2,4-triazolopyridine 9 were obtained by catalytic hydrogenation.The reduction of triazolopyridine 8 using stannous chloride led to the intermediate compound 10 which with acetic anhydride afforded 8-acetylamino-5-chloro-1,2,4-triazolopyridine 10a.The structure of the derivatives was determined by 1H-nmr (DMSO-d6).