31053-03-9

Basic information

• Product Name: Piperidine, 1-(4-Methylphenyl)-
• Synonyms: Piperidine, 1-(4-Methylphenyl)-
• CAS NO: 31053-03-9
• Molecular Formula: C₁₂H₁₇N
• Molecular Weight: 175.27008
• Mol File: 31053-03-9.mol
• Article Data: 107

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Piperidine, 1-(4-Methylphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Piperidine, 1-(4-Methylphenyl)-(31053-03-9)
• EPA Substance Registry System: Piperidine, 1-(4-Methylphenyl)-(31053-03-9)

Safety Data

• Hazardous Substances Data: 31053-03-9(Hazardous Substances Data)

Usage

General Description

Piperidine, 1-(4-methylphenyl)- is a chemical compound that is also known as 1-(4-methylphenyl)-piperidine. It is a member of the piperidine class of compounds, which are organic compounds that contain a six-membered ring consisting of five carbon atoms and one nitrogen atom. This particular compound has a methylphenyl group attached to the piperidine ring, giving it distinct chemical properties and potential applications. Piperidine derivatives like 1-(4-methylphenyl)-piperidine are used in the synthesis of pharmaceuticals and agrochemicals, and they also have potential applications in materials science and other fields. Furthermore, piperidines are known to have biological activity and have been studied for their potential pharmacological effects.

Upstream product

• 110-89-4 piperidine 
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Downstream Products

• 88320-32-5 2,2,2-trifluoro-1-<5-methyl-2-(1-piperidinyl)phenyl>ethanone 
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• 860573-35-9 (5-bromo-pentyl)-p-tolyl-carbamonitrile 
• 32117-01-4 1-(4-methyl-2-nitrophenyl)piperidine 
• 1041766-84-0 1-(p-tolyl)piperidine-2-carbonitrile 

Relevant articles and documents

Substituent effects in the gas-phase pyrolysis of 4-(N/-arylamino)-1-butyl acetate and 5-(N/-arylamino)-1-pentyl acetate

A kinetic study of the gas-phase pyrolysis of 4- and 5-(N-arylamino)-1-butyl and -1-pentyl acetate was mace. Each ester was pyrolysed at five or six different temperatures and over a temperature range not less than 50 °C. These reactions were homogeneous and unimolecular. The reactivities of these compounds were compared with those of the parent compounds 4- and 5-(N-phenyl)-1-butyl and -1-pentyl acetate and with each other. The products of the decomposition reaction of these compounds suggest an anchimeric assistance of the amino substituen for a trans elimination, indicating that an ion-pair type of mechanism may be operating during the process of elimination. Copyright

Catalytic Amination of Phenols with Amines

Given the wide prevalence and ready availability of both phenols and amines, aniline synthesis through direct coupling between these starting materials would be extremely attractive. Herein, we describe a rhodium-catalyzed amination of phenols, which provides concise access to diverse anilines, with water as the sole byproduct. The arenophilic rhodium catalyst facilitates the inherently difficult keto–enol tautomerization of phenols by means of π-coordination, allowing for the subsequent dehydrative condensation with amines. We demonstrate the generality of this redox-neutral catalysis by carrying out reactions of a large array of phenols with various electronic properties and a wide variety of primary and secondary amines. Several examples of late-stage functionalization of structurally complex bioactive molecules, including pharmaceuticals, further illustrate the potential broad utility of the method.

Iodine-Mediated Coupling of Cyclic Amines with Sulfonyl Hydrazides: an Efficient Synthesis of Vinyl Sulfone Derivatives

An efficient iodine-mediated coupling of cyclic amines with sulfonyl hydrazides is reported. This transformation opens a new route to the synthesis of vinyl sulfones derivatives, which is a common structural motif in natural products and pharmaceuticals. Tentative mechanistic studies suggest that this reaction is likely to involve a radical process.

CuI/2-Aminopyridine 1-Oxide Catalyzed Amination of Aryl Chlorides with Aliphatic Amines

A class of 2-aminopyridine 1-oxides are discovered to be effective ligands for the Cu-catalyzed amination of less reactive (hetero)aryl chlorides. A wide range of functionalized (hetero)aryl chlorides reacted with various aliphatic amines to afford the desired products in good to excellent yields under the catalyst of CuI/2-aminopyridine 1-oxides. Furthermore, the catalyst system worked well for the coupling of cyclic secondary amines and N-methyl benzylamine with (hetero)aryl chlorides.