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5-Nitro-2'-deoxyuridine (5-NdU) is a synthetic nucleoside analog of the naturally occurring nucleoside thymidine, which plays a crucial role in DNA synthesis. It is characterized by the presence of a nitro group at the 5-position of the uracil base and a deoxyribose sugar at the 2' position. 5-NdU is often used in molecular biology and chemical biology research to study DNA replication, repair, and mutagenesis. Due to its structural similarity to thymidine, it can be incorporated into DNA by DNA polymerases, leading to the formation of DNA adducts and potentially causing mutations. This property makes 5-NdU a valuable tool for investigating the mechanisms of DNA damage and repair, as well as for developing new therapeutic strategies for cancer and other diseases.

3106-01-2

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3106-01-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 3106-01-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,1,0 and 6 respectively; the second part has 2 digits, 0 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 3106-01:
(6*3)+(5*1)+(4*0)+(3*6)+(2*0)+(1*1)=42
42 % 10 = 2
So 3106-01-2 is a valid CAS Registry Number.

3106-01-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-nitropyrimidine-2,4-dione

1.2 Other means of identification

Product number -
Other names 5-Nitro-dUrd

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:3106-01-2 SDS

3106-01-2Relevant academic research and scientific papers

Synergistic effect of 5-nitro-2'-deoxyuridine with ganciclovir against human cytomegalovirus in vitro

Rao,Rando,Huffman,Revankar

, p. 1997 - 2008 (2007/10/02)

In this paper we describe a practical synthesis of 5-nitro-2'- deoxyuridine (4) and 1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-5-nitrouracil (11). These compounds were then evaluated for their ability to inhibit the growth of human cytomegalovirus (HCMV, strain AD169) in MRC-5 cells using a plaque reduction assay. Compound 11 was unable to inhibit the growth of HCMV at the highest concentration tested (100 μg/mL). However, compound 4 (5- NO2-dU) exhibited marginal activity against HCMV in vitro in a dose- dependent manner with a 50% inhibitory concentrations (IC50) of 1 to 5 μg/mL. Combinations of 5-NO2-dU with ganciclovir synergistically inhibited HCMV induced cell killing in culture.

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