960319-22-6Relevant academic research and scientific papers
Novel method for the synthesis of 3-monosubstituted six-membered benzosultams
Fang, Fang,Wang, Rui,Liu, Zhao-Peng,Ji, Ai-Guo
, p. 2377 - 2388 (2008/09/18)
3-Monosubstituted six-membered benzosultams with a wide range of functional groups were prepared by simple and convenient two-step procedures. o-Lithiation of N-Boc-o-toluenesulfonamide followed by reaction with aldehydes gave carbinol sulfonamides, which were converted to 3-monosubstituted six-membered benzosultams via TMSCI/NaI/MeCN reagent mediated cyclization. The mechanism and the scope of this novel transformation are studied.
