31127-40-9

Basic information

• Product Name: 6-(azidomethyl)-2,3-dihydrobenzo[b][1,4]dioxine hydrochloride
• Synonyms: 6-(azidomethyl)-2,3-dihydrobenzo[b][1,4]dioxine hydrochloride;(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)methanamine hydrochloride;1,4-Benzodioxan-6-methylamine Hydrochloride
• CAS NO: 31127-40-9
• Molecular Formula: C₉H₁₁NO₂*ClH
• Molecular Weight: 227.6476
• Mol File: 31127-40-9.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 6-(azidomethyl)-2,3-dihydrobenzo[b][1,4]dioxine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 6-(azidomethyl)-2,3-dihydrobenzo[b][1,4]dioxine hydrochloride(31127-40-9)
• EPA Substance Registry System: 6-(azidomethyl)-2,3-dihydrobenzo[b][1,4]dioxine hydrochloride(31127-40-9)

Safety Data

• Hazardous Substances Data: 31127-40-9(Hazardous Substances Data)

Usage

Uses

1,4-Benzodioxan-6-methylamine hydrochloride is a reagent that iss used in the preparation of 4-(4-hydroxy-3,5-dimethoxyphenyl)-6,7-dimethoxy-dihydroisoquinolin-3-one.

Upstream product

• 29668-44-8 2,3-dihydro-benzo[1,4]dioxin-6-carbaldehyde 
• 31127-39-6 2,3-dihydrobenzo[b][1,4]dioxin-6-carbaldoxime 
• 17413-10-4 2,3-dihydro-1,4-benzodioxin-6-ylmethylamine 

Downstream Products

• 1175086-06-2 (2,3-dihydro-benzo[1,4]dioxin-6-ylmethyl)-[1-(3-iodo-phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]amine 
• 1175086-30-2 (2,3-dihydro-benzo[1,4]dioxin-6-ylmethyl)-[1-(3,5-dimethyl-phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]-amine 

Relevant articles and documents

Reusable Nickel Nanoparticles-Catalyzed Reductive Amination for Selective Synthesis of Primary Amines

The preparation of nickel nanoparticles as efficient reductive amination catalysts by pyrolysis of in situ generated Ni-tartaric acid complex on silica is presented. The resulting stable and reusable Ni-nanocatalyst enables the synthesis of functionalized and structurally diverse primary benzylic, heterocyclic and aliphatic amines starting from inexpensive and readily available carbonyl compounds and ammonia in presence of molecular hydrogen. Applying this Ni-based amination protocol, -NH2 moiety can be introduced in structurally complex compounds, for example, steroid derivatives and pharmaceuticals.

Sodium nitrite-catalyzed aerobic oxidative Csp2-Csp3 coupling: Direct construction of the 4-aryldihydroisoquinolinone moiety

A bioinspired approach for the construction of the 4- aryldihydroisoquinolinone moiety via direct oxidative Csp2-Csp 3 coupling has been developed, which uses inexpensive sodium nitrite as catalyst and environmentally benign oxygen in the air as terminal oxidant.

Anthranilic acid derivatives as inhibitors of the cGMP-phosphodiesterase

Compounds of formula (I) STR1where R 1 is hydrogen; R 2 is nitro, cyano or halo(lower)alkyl; R 3 is phenyl substituted with one or more substituents selected from halogen, cyano and lower alkoxy; A is a lower alkylene group; R 4 is a group CR 6 R 7 R 8 wherein R 6 and R 7 form, together with the carbon atom to which they are attached a cycloalkyl group optionally substituted with hydroxy, lower alkoxy or a lower alkanoylamino; and R 8 is hydrogen; its prodrug and a salt thereof.