31127-85-2

Basic information

• Product Name: alpha, oMega-Dipropionic acid triethylene glycol
• Synonyms: alpha, oMega-Dipropionic acid triethylene glycol;HOOC-PEG3-COOH;α,ω-Dipropionic acid triethylene glycol;4,7,10,13-Tetraoxahexadecanedioic acid;Bis-PEG4-acid;Bis-PEG5-acid;4,7,10,13-Tetraoxa-hexadecan-1,16-dicarbonsaeure;4,7,10,13-Tetraoxahexadecane-1,16-dioic acid
• CAS NO: 31127-85-2
• Molecular Formula: C₁₂H₂₂O₈
• Molecular Weight: 294
• EINECS: 228-394-1
• Mol File: 31127-85-2.mol

Chemical Properties

• Boiling Point: 483.7±45.0 °C(Predicted)
• Appearance: /
• Density: 1.219±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: Soluble in Water, DMSO, DCM, DMF
• PKA: 3.97±0.10(Predicted)
• CAS DataBase Reference: alpha, oMega-Dipropionic acid triethylene glycol(CAS DataBase Reference)
• NIST Chemistry Reference: alpha, oMega-Dipropionic acid triethylene glycol(31127-85-2)
• EPA Substance Registry System: alpha, oMega-Dipropionic acid triethylene glycol(31127-85-2)

Safety Data

• Hazardous Substances Data: 31127-85-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
alpha, oMega-Dipropionic acid triethylene glycol is used as a PEG linker for improving the solubility and stability of therapeutic molecules. The hydrophilic PEG spacer increases the aqueous solubility of the linked molecules, while the terminal carboxylic acids allow for the formation of stable amide bonds with primary amine groups, enhancing the overall stability and bioavailability of the drug.
Used in Drug Delivery Systems:
In the field of drug delivery, alpha, oMega-Dipropionic acid triethylene glycol is used as a versatile PEG linker to enhance the properties of drug carriers. The hydrophilic PEG spacer can improve the solubility and biocompatibility of drug carriers, such as nanoparticles or liposomes, while the terminal carboxylic acids enable covalent attachment of therapeutic molecules, ensuring their controlled release and targeted delivery to the desired site of action.
Used in Bioconjugation:
alpha, oMega-Dipropionic acid triethylene glycol is also used as a PEG-based bioconjugation agent for the attachment of various biomolecules, such as proteins, peptides, or antibodies, to other molecules or surfaces. The hydrophilic PEG spacer provides a flexible and hydrophilic environment for the biomolecule, while the terminal carboxylic acids facilitate the formation of stable amide bonds with primary amine groups on the target molecule or surface, enhancing the stability and bioactivity of the resulting bioconjugate.

Upstream product

• 64-18-6 formic acid 
• 112-27-6 2,2'-[1,2-ethanediylbis(oxy)]bisethanol 
• 57741-46-5 α,ω-di(cyanoethylene)triethylene tetraoxide 
• 31127-83-0 4,7,10,13-tetraoxa-hexadecanedioic acid diethyl ester 

Downstream Products

• 31127-82-9 Iodoxamic acid 
• 51134-98-6 C₃₆H₄₄I₆N₄O₁₂ 
• 25901-41-1 C₃₂H₃₆I₆N₄O₁₂ 
• 51211-03-1 C₃₀H₃₂I₆N₄O₁₂ 

Relevant articles and documents

BIFUNCTIONAL COMPOUNDS FOR DEGRADING BTK VIA UBIQUITIN PROTEOSOME PATHWAY

The present invention relates to compounds useful for degrading BTK via a ubiquitin proteolytic pathway. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.

PEPTIDIC LINKERS AND CRYPTOPHYCIN CONJUGATES, USEFUL IN THERAPY, AND THEIR PREPARATION

The present disclosure relates to compounds of formula (I): RCG1-L-P (I) wherein RCG1 represents a reactive chemical group being reactive towards a chemical group present on a polypeptide such as an antibody; P represents H, OH or an activated O; and L represents a specific linker. The disclosure also relates to cryptophycin payloads, as well as to cryptophycin conjugates, to compositions containing them and to their therapeutic use, especially as anticancer agents. The disclosure also relates to the process for preparing these conjugates.

Intramolecular End-to-End Reactions of Photoactive Terminal Groups Linked by Poly(oxyethylene) Chains

The triplet-sensitized photochemical reaction using a series of poly(oxyethylene) chains with a pair of photoactive terminal groups, dibenzazepine (DBA) chromophores (DBA-COCH2CH2(OCH2CH2)nOCH2CH2CO-DBA, n=0-10) was examined.The photoirradiation of bichromophoric compounds caused either intra- or intermolecular reactions.These reactions were kinetically analyzed by two different methods: the measurement of deactivation processes of the reaction intermediates (excited triplet state of DBA) by nanosecond laser photolysis and the quantitative analysis of the reaction products by GPC.The intramolecular deactivation rate constant, kintra, showed a remarkable chain-length dependence; the maximum kintra value appeared at n=5 and it was found to be 5.9X104 s-1.On the other hand, the intramolecular cyclization rate also depends on the chain length; the maximum quantum yield, φintrad, was given at n=7 (φintrad=0.51).The chain length for the maximum cyclization yield shifted slightly to the longer region than that for the maximum kintra value due to the restriction of the terminal structure (anti-configuration).The results obtained for this reaction system are compared with those obtained for the previously reported polymethylene system and the effect of chain flexibility on the intramolecular ring-closure reaction is discussed.

Radiopaque contrast media. XXIV. Synthesis and structure activity relationships of new hexaiodinated radiopaque compounds

The synthesis of a series of new hexaiodinated radiopaque compounds is described. The relationship of structure to tolerability and biliary and urinary excretion was studied. Optimum tolerability was achieved with a compound which has been selected for further investigation as an angiographic contrast agent of the 'dimer' type. Iodoxamic acid showed a high biliary excretion combined with good tolerability, and is being developed as an injectable cholecystographic agent.