311313-24-3

Upstream product

• 99-94-5 p-Toluic acid 
• 618-94-0 3-nitrobenzoic acid hydrazide 

Downstream Products

• 1226232-72-9 C₁₅H₁₃N₃S 
• 1418206-11-7 C₂₂H₂₀N₄ 
• 775302-21-1 3-(5-p-tolyl-1,3,4-oxadiazol-2-yl)aniline 
• 831215-29-3 2-(4-chlorophenyl)-N-(3-(5-p-tolyl-1,3,4-oxadiazol-2-yl)phenyl)acetamide 
• 1418206-28-6 2-p-tolyl-N-(3-(5-p-tolyl-1,3,4-oxadiazol-2-yl)phenyl)acetamide 
• 1418206-29-7 2-(3,4-dihydroxyphenyl)-N-(3-(5-p-tolyl-1,3,4-oxadiazol-2-yl)phenyl)acetamide 
• 1418206-04-8 4-benzyl-3-(3-nitrophenyl)-5-p-tolyl-4H-1,2,4-triazole 
• 1418206-30-0 2-(3,4-dimethoxyphenyl)-N-(3-(5-p-tolyl-1,3,4-thiadiazol-2-yl)phenyl)acetamide 
• 1418206-31-1 N-(3-(4-benzyl-5-p-tolyl-4H-1,2,4-triazol-3-yl)phenyl)-2-(3,4-dimethoxyphenyl)acetamide 
• 1418206-39-9 2-(3,4-dimethoxyphenyl)-N-(3-(5-p-tolyl-4H-1,2,4-triazol-3-yl)phenyl)acetamide 
• 717828-35-8 2-(3,4-dimethoxyphenyl)-N-(3-(5-p-tolyl-1,3,4-oxadiazol-2-yl)phenyl)acetamide 
• 1620517-21-6 C₁₉H₁₇N₃O₄ 
• 1620517-22-7 C₂₀H₁₉N₃O₄ 
• 1620517-26-1 C₂₃H₂₅N₃O₄ 

Relevant academic research and scientific papers

Synthesis and structure-activity relationship of non-phosphorus-based fructose-1,6-bisphosphatase inhibitors: 2,5-Diphenyl-1,3,4-oxadiazoles

With the aim of discovering a novel class of non-phosphorus-based fructose-1,6-bisphosphatase (FBPase) inhibitors, a series of 2,5-diphenyl-1,3,4-oxadiazoles were synthesized based on the hit compound (1) resulting from a high-throughput screening (HTS). Structure-activity relationship (SAR) studies led to the identification of several compounds with comparable inhibitory activities to AMP, the natural allosteric inhibitor of FBPase. Notably, compound 22 and 27b, bearing a terminal carboxyl or 1H-tetrazole, demonstrated remarkable inhibition to gluconeogenesis (GNG). In addition, both inhibition and binding mode to the enzyme were investigated by enzymatic kinetics and in silico experiments for representative compounds 16 and 22.

Design, synthesis and biological activity evaluation of 2,5-diphenyl-1,3,4-oxadiazole derivatives as novel inhibitors of fructose-1,6-bisphosphatase

Fructose-1,6-bisphosphatase (FBPase), an important gluconeogenic enzyme, catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate. The effort to discover new FBPase inhibitors was carried out by high-throughput screening (HTS) of a library of 56,000 lead-like compounds, and a 2,5-diphenyl-1,3,4-oxadiazole (3a, IC50 = 15.45 μM) which bearing no phosphate group was identified as a potential FBPase inhibitor for the first time. Structure-activity-relationship (SAR) research of a series of analogues obtained by modifying the substituent groups and replacing the 1,3,4-oxadiazole with several other heterocycles disclosed the key structure and substituent groups related to the binding with FBPase.

Diaryl substituted thiazoles useful in the treatment of fungal infections

Disclosed is a novel class of thiazole, thiadiazole, and oxadiazole compounds which are substituted at their nuclear carbons by aromatic moieties. These compounds exhibit antifungal activity against a variety of fungi including strains which have proven to be resistant to treatment with known antifungal agents such as Fluconazole.