311313-24-3

Basic information

• Product Name: Benzoic acid, 3-nitro-, 2-(4-methylbenzoyl)hydrazide
• CAS NO: 311313-24-3
• Molecular Formula: C15H13N3O4
• Molecular Weight: 299.286
• Mol File: 311313-24-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 3-nitro-, 2-(4-methylbenzoyl)hydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 3-nitro-, 2-(4-methylbenzoyl)hydrazide(311313-24-3)
• EPA Substance Registry System: Benzoic acid, 3-nitro-, 2-(4-methylbenzoyl)hydrazide(311313-24-3)

Safety Data

• Hazardous Substances Data: 311313-24-3(Hazardous Substances Data)

Upstream product

• 99-94-5 p-Toluic acid 
• 618-94-0 3-nitrobenzoic acid hydrazide 

Downstream Products

• 1226232-72-9 C₁₅H₁₃N₃S 
• 1418206-11-7 C₂₂H₂₀N₄ 
• 775302-21-1 3-(5-p-tolyl-1,3,4-oxadiazol-2-yl)aniline 
• 831215-29-3 2-(4-chlorophenyl)-N-(3-(5-p-tolyl-1,3,4-oxadiazol-2-yl)phenyl)acetamide 
• 1418206-28-6 2-p-tolyl-N-(3-(5-p-tolyl-1,3,4-oxadiazol-2-yl)phenyl)acetamide 
• 1418206-29-7 2-(3,4-dihydroxyphenyl)-N-(3-(5-p-tolyl-1,3,4-oxadiazol-2-yl)phenyl)acetamide 
• 1418206-04-8 4-benzyl-3-(3-nitrophenyl)-5-p-tolyl-4H-1,2,4-triazole 
• 1418206-30-0 2-(3,4-dimethoxyphenyl)-N-(3-(5-p-tolyl-1,3,4-thiadiazol-2-yl)phenyl)acetamide 
• 1418206-31-1 N-(3-(4-benzyl-5-p-tolyl-4H-1,2,4-triazol-3-yl)phenyl)-2-(3,4-dimethoxyphenyl)acetamide 
• 1418206-39-9 2-(3,4-dimethoxyphenyl)-N-(3-(5-p-tolyl-4H-1,2,4-triazol-3-yl)phenyl)acetamide 
• 717828-35-8 2-(3,4-dimethoxyphenyl)-N-(3-(5-p-tolyl-1,3,4-oxadiazol-2-yl)phenyl)acetamide 
• 1620517-21-6 C₁₉H₁₇N₃O₄ 
• 1620517-22-7 C₂₀H₁₉N₃O₄ 
• 1620517-26-1 C₂₃H₂₅N₃O₄ 

Relevant articles and documents

Synthesis and structure-activity relationship of non-phosphorus-based fructose-1,6-bisphosphatase inhibitors: 2,5-Diphenyl-1,3,4-oxadiazoles

With the aim of discovering a novel class of non-phosphorus-based fructose-1,6-bisphosphatase (FBPase) inhibitors, a series of 2,5-diphenyl-1,3,4-oxadiazoles were synthesized based on the hit compound (1) resulting from a high-throughput screening (HTS). Structure-activity relationship (SAR) studies led to the identification of several compounds with comparable inhibitory activities to AMP, the natural allosteric inhibitor of FBPase. Notably, compound 22 and 27b, bearing a terminal carboxyl or 1H-tetrazole, demonstrated remarkable inhibition to gluconeogenesis (GNG). In addition, both inhibition and binding mode to the enzyme were investigated by enzymatic kinetics and in silico experiments for representative compounds 16 and 22.

Diaryl substituted thiazoles useful in the treatment of fungal infections

Disclosed is a novel class of thiazole, thiadiazole, and oxadiazole compounds which are substituted at their nuclear carbons by aromatic moieties. These compounds exhibit antifungal activity against a variety of fungi including strains which have proven to be resistant to treatment with known antifungal agents such as Fluconazole.