311332-19-1

Basic information

• Product Name: C₁₇H₁₃N₃O₅
• CAS NO: 311332-19-1
• Molecular Weight: 339.307
• Mol File: 311332-19-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₇H₁₃N₃O₅(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₇H₁₃N₃O₅(311332-19-1)
• EPA Substance Registry System: C₁₇H₁₃N₃O₅(311332-19-1)

Safety Data

• Hazardous Substances Data: 311332-19-1(Hazardous Substances Data)

Upstream product

• 641-70-3 3-nitrophthalic acid anhydride 
• 76521-40-9 2-(4-nitro-1,3-dioxoisoindolin-2-yl)acetyl chloride 
• 100-46-9 benzylamine 
• 15784-35-7 2-(4-nitro-1,3-dioxoisoindolin-2-yl)acetic acid 

Relevant articles and documents

Synthesis and screening of cyclooxygenase inhibitory activity of some 1,3-dioxoisoindoline derivatives

In this study, 15 compounds bearing N,Nphthaloylacetamide structure designed by the molecular simplification approach based on thalidomide structure were synthesized and evaluated for inhibitory potencies against cyclooxgenase (COX) isoenzymes, namely COX-1 and COX-2. The results suggested that the N,Nphthaloylacetamide structure, as a primary amide, has inhibitory activity against cyclooxygenase isoenzymes with a higher COX-1 selectivity. The conversion of the primary amide to secondary or tertiary derivatives lowered the potency but favored the COX-2 selectivity thus yielding the compounds with stronger COX-2 inhibiting activity. ECV · Editio Cantor Verlag.