15784-35-7Relevant articles and documents
N-acetamido galactose modified 3-nitrophthalimide derivative, preparation method, application and liver targeting probe
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Paragraph 0041; 0045-0046, (2020/10/20)
The invention provides an N-acetamido galactose modified 3-nitrophthalimide derivative, a preparation method and an application of the N-acetamido galactose modified 3-nitrophthalimide derivative, anda liver targeting probe. The preparation method of the fluorescent probe is simple, and the obtained fluorescent probe takes N-acetamido galactose as a liver targeting group and 3-nitrophthalimide asa CO response group, can be used as a CO detection reagent, is good in selectivity and high in sensitivity, can target liver cells and liver tissues, and can be used for dynamically monitoring the COlevel.
SMALL MOLECULES AGAINST CEREBLON TO ENHANCE EFFECTOR T CELL FUNCTION
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Page/Page column 140, (2017/10/11)
Disclosed are small molecules against cereblon to enhance effector T cell function. Methodos of making thes molecules and methods of using them to treat various disease states are also disclosed.
Synthesis and screening of cyclooxygenase inhibitory activity of some 1,3-dioxoisoindoline derivatives
Cizmecioglu, Murat,Pabuccuoglu, Varol,Ballar, Petek,Pabuccuoglu, Aysun,Soyer, Zeynep
experimental part, p. 186 - 190 (2011/10/10)
In this study, 15 compounds bearing N,Nphthaloylacetamide structure designed by the molecular simplification approach based on thalidomide structure were synthesized and evaluated for inhibitory potencies against cyclooxgenase (COX) isoenzymes, namely COX-1 and COX-2. The results suggested that the N,Nphthaloylacetamide structure, as a primary amide, has inhibitory activity against cyclooxygenase isoenzymes with a higher COX-1 selectivity. The conversion of the primary amide to secondary or tertiary derivatives lowered the potency but favored the COX-2 selectivity thus yielding the compounds with stronger COX-2 inhibiting activity. ECV · Editio Cantor Verlag.