31136-75-1Relevant academic research and scientific papers
A carbon dioxide-promoted three-component Strecker reaction
Fauziev, Ruslan V.,Ivanov, Roman E.,Kuchurov, Ilya V.,Zlotin, Sergei G.
, p. 10137 - 10144 (2021/12/24)
A three-component Strecker reaction of aldehydes, amines and KCN has been performed for the first time in supercritical carbon dioxide. In the proposed procedure, non-toxic and non-flammable carbon dioxide acts not only as an environmentally benign reaction medium but also as a reaction promoter via in situ formation of carbonic acid which provides a gradual release of the true cyanating agent (HCN) from available KCN. The reaction conditions (pressure, temperature, and concentrations of reagents) were optimized, and various aromatic and aliphatic amines and aldehydes were transformed into valuable α-amino nitriles including prospective pharmacological substances. The equimolar amount of used cyanogen reagent, carrying out the process in a sealed autoclave in a 'green' solvent medium under mild conditions (90 bar, 35 °C) along with the high yields of products and the scalability of the developed procedure make it suitable for sustainable industrial applications. This journal is
Cyano-borrowing: Titanium-catalyzed direct amination of cyanohydrins with amines and enantioselective examples
Li, Qian,Li, Qing-Hua,Li, Wan-Fang,Li, Zhao-Feng,Liu, Tang-Lin,Peng, Yun-Gui,Ren, Li-Qing,Tao, Jing
supporting information, p. 651 - 654 (2020/01/28)
The direct amination of cyanohydrins with amines via a catalytic cyano-borrowing reaction was developed. The transformation features broad substrate scope, excellent functional group compatibility, and very mild and simple operations. Moreover, a titanium
Highly efficient three-component Strecker-type reaction catalyzed by MgI2 etherate under solvent-free conditions
Li, Pengcheng,Zhang, Yongdong,Chen, Zhili,Zhang, Xingxian
supporting information, p. 1854 - 1858 (2017/04/21)
A concise, straightforward and efficient method has been developed for the synthesis of α-aminonitriles by an one-pot three-component condensation of aldehydes or ketones, amines and trimethylsilyl cyanide catalyzed by MgI2 etherate under solvent-free conditions. This protocol has some advantages such as mild reaction condition, simple work-up, short reaction time and high product yields.
MgI2 etherate-catalysed Strecker reaction: A facile and efficient synthesis of α-aminonitriles from aldimines and trimethylsilyl cyanide
Lu, Yongping,Wang, Yanping,Zhang, Xingxian
, p. 709 - 711 (2014/01/17)
A mild and efficient procedure for the synthesis of a-aminonitriles is achieved by treatment of aldimines with trimethylsilyl cyanide catalysed by MgI2 etherate.
Cu(OTf)2 or Et3N-catalyzed three-component condensation of aldehydes, amines and cyanides: a high yielding synthesis of α-aminonitriles
Paraskar, Abhimanyu S.,Sudalai, Arumugam
, p. 5759 - 5762 (2007/10/03)
Copper(II) triflate or Et3N have been found to catalyze, under ambient conditions, the addition of a cyanide anion, such as trimethylsilyl cyanide or acetone cyanohydrin, onto in situ generated imines, furnishing α-aminonitriles in excellent yi
Intramolecular Diels-Alder Reaction with Furans: Effect of the Substitution Pattern Reinvestigated
Prajapati, Dipak,Borthakur, Dipak R.,Sandhu, Jagir S.
, p. 1197 - 1200 (2007/10/02)
Intramolecular Diels-Alder reactions occurred smoothly when N-(α-cyanofurfuryl)arylamines 2a-g and N-furfurylarylamines 7a-d were treated with maleic anhydride and fumaroyl chloride-triethylamine respectively, to afford the corresponding cycloadducts 4 an
