31145-62-7Relevant academic research and scientific papers
Preparation method of 3,4-dihydro-2H-1-benzopyran-2-carboxylic acid compound and application thereof
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Paragraph 0045; 0048; 0049, (2018/07/15)
Disclosed are a preparation method of a 3,4-dihydro-2H-1-benzopyran-2-carboxylic acid compound and application thereof. The invention relates to the field of organic synthesis. According to the method, a phenolic compound is reacted with a gamma-butyrrolactone compound under the action of alkalis to obtain an intermediate; ring-closing reaction is conducted on the intermediate under the action ofacid catalysts, and the 3,4-dihydro-2H-1-benzopyran-2-carboxylic acid compound is obtained with high efficiency and high yield only by two simple steps of reaction; the preparation method has the advantages of being simple in routine design and procedures, convenient to operate and low in cost, and the method is very suitable for industrialized large-scale production; by applying the preparation method of the 3,4-dihydro-2H-1-benzopyran-2-carboxylic acid compound to the application for preparing medicines with the structure of 3,4-dihydro-2H-1-benzopyran-2-carboxylic acid, the yield of the medicines can be improved and the production cost can be reduced.
