31167-04-1

Basic information

• Product Name: 2,4-Dimethyl-3-nitroaniline
• Synonyms: 2,4-Dimethyl-3-nitroaniline;2,4-Dimethyl-3-nitrobenzenamine;3-Nitro-2,4-xylidine;3-nitro-2,4-dimethylaniline
• CAS NO: 31167-04-1
• Molecular Formula: C₈H₁₀N₂O₂
• Molecular Weight: 166.18
• Mol File: 31167-04-1.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2,4-Dimethyl-3-nitroaniline(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-Dimethyl-3-nitroaniline(31167-04-1)
• EPA Substance Registry System: 2,4-Dimethyl-3-nitroaniline(31167-04-1)

Safety Data

• Hazardous Substances Data: 31167-04-1(Hazardous Substances Data)

Usage

Physical state

Yellow crystalline solid

Uses

Production of dyes and pigments, intermediate in the synthesis of pharmaceuticals and other organic compounds

Hazard classification

Hazardous substance

Health and environmental risks

Potential health and environmental risks require careful handling and proper safety procedures to prevent exposure and minimize adverse effects.

Upstream product

• 95-68-1 2,4-Xylidine 
• 7664-93-9 sulfuric acid 
• 81-20-9 2,6-dimethylnitrobenzene 
• 603-02-1 2,4-dinitro-m-xylene 

Downstream Products

• 81-20-9 2,6-dimethylnitrobenzene 
• 61149-81-3 N,N-dimethyl-2,4,5-trinitro-aniline 
• 13438-26-1 2,6-dimethylbenzene-1,3-diamine 
• 39053-43-5 1-bromo-2,4-dimethyl-3-nitro-benzene 
• 74709-95-8 2,6-dimethyl-p-dinitrobenzene 
• 108906-85-0 1,3-dimethyl-2,4,5-trinitro-benzene 
• 61920-54-5 2,4-dimethyl-3,6-dinitro-aniline 
• 861611-26-9 acetic acid-(2,4-dimethyl-3,6-dinitro-anilide) 
• 81115-59-5 5-methyl-4-nitroindazol 
• 70261-49-3 2,4-dimethyl-3-nitrophenol 
• 92149-68-3 (3-Nitro-2,4-xylyl)-(4-nitro-phenyl)-ether 
• 133053-89-1 N'-(2,4-dimethyl-3-nitrophenyl)-N,N-dimethylformamidine 
• 39182-88-2 acetic acid-(2,4-dimethyl-3-nitro-anilide) 

Relevant articles and documents

PYRAZOLOPYRIMIDINE DERIVATIVES, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION FOR USE IN PREVENTING OR TREATING CANCER, AUTOIMMUNE DISEASE AND BRAIN DISEASE CONTAINING THE SAME AS AN ACTIVE INGREDIENT

The present invention relates to a pyrazolopyrimidine derivative, a preparation method thereof and a pharmaceutical composition comprising the same as an active ingredient for the prevention or treatment of cancer, autoimmune disease and brain disease. The pyrazolopyrimidine derivative of the present invention exhibits excellent Bruton's tyrosine kinase inhibition activity, so that it can be effectively used as a pharmaceutical composition for the prevention or treatment of cancer, autoimmune disease and Parkinson's disease.

Phenyl-and aminophenyl-alkylsulfonamide and urea derivatives, their preparation and their use as alpha1A/1L adrenoceptor agonists

The present invention concerns novel compounds represented by the Formula:*(formula 02)* wherein: A is R1q(R3R60N)m(Z)(NR2)n; m and q are each 0 or 1, with the proviso that when q is 1, m is 0 and when q is 0, m is 1; Z is C=O or SO 2; n is 1 with the proviso that, when Z is C=O, m is 1; X is -NH-, -CH2-, or -OCH2-; Y is 2-imidazoline, 2-oxazoline, 2-thiazoline, or 4-imidazole; R 1 is H, lower alkyl, or phenyl, with the proviso that, when R1 is H, m is 1; R2, R3, R60 are each independently H, lower alkyl, or phenyl; R4, R5, R6, and R7 are each independently hydrogen, lower alkyl, - CF 3, lower alkoxy, halogen, phenyl, lower alkeny, hydroxyl, lower alkylsulfonamido, or lower cycloalkyl, wherein R2 and R7 optionally may be taken together to form alkylene or alkenylene of 2 to 3 atoms in an unsubstituted or optionally substituted 5-or 6-membered ring, wherein the optional substituents on the ring are halo, lower alkyl, or -CN,with the proviso that, when R7 is hydroxyl or lower alkylsulfonamido, then X is not -NH- when Y is 2-imidazoline. The compounds include pharmaceutically acceptable salts of the above. In the above formula A may be, for example, (R1SO2NR2-), (R3R60NSO2NR2-), or (R3R60NCONR2-). The invention also includes the use of the above compounds, and compositions containing them, as alpha 1A/1L agonists in the treatment of various disease states such as urinary incontinence, nasal congestion, priapism, depression, anxiety, dementia, senility, Alzheimer's, deficiencies in attentiveness and cognition, and eating disorders such as obesity, bulimia, and anorexia.

Direct Nitration of Anilines Using Nitrocyclohexadienones

Nitrocyclohexadienones (in particular, 2,3,5,6-tetrabromo-4-methyl-4-nitro-2,5-cyclohexadienone) are used as reagents for the direct nitration of anilines.Depending on the conditions, good yields of C-nitroanilines are obtained.Under the same conditions, N,N-dimethylaniline is converted into N-methyl-N-nitroaniline.