603-02-1

Usage

Uses

Used in Chemical Synthesis:
2,4-Dinitro-m-xylene is used as an intermediate for the synthesis of various organic compounds, such as dyes, pharmaceuticals, and pesticides. Its presence in these compounds is crucial for their color, therapeutic effects, and pest control properties.
Used in Dye Industry:
2,4-Dinitro-m-xylene is used as a chemical intermediate for the production of dyes. Its role in the synthesis process contributes to the development of dyes with specific color characteristics and properties.
Used in Pharmaceutical Industry:
2,4-Dinitro-m-xylene is used as a chemical intermediate in the synthesis of pharmaceuticals. Its involvement in the production process helps in the creation of drugs with desired therapeutic effects and properties.
Used in Pesticide Industry:
2,4-Dinitro-m-xylene is used as a chemical intermediate in the formulation of pesticides. Its contribution to the synthesis process aids in the development of pesticides with effective pest control properties.

Upstream product

• 81-20-9 2,6-dimethylnitrobenzene 
• 108-38-3 m-xylene 
• 7697-37-2 nitric acid 
• 7664-93-9 sulfuric acid 
• 632-92-8 2,4-dimethyl-1,3,5-trinitrobenzene 
• 89-87-2 2,4-dimethylnitrobenzene 
• 67083-28-7 2,6-dimethyl-3-nitroaniline 

Downstream Products

• 92149-68-3 (3-Nitro-2,4-xylyl)-(4-nitro-phenyl)-ether 
• 70261-49-3 2,4-dimethyl-3-nitrophenol 
• 94135-19-0 2,4-dimethyl-benzene-1,3,5-triyltriamine 
• 31167-04-1 (2,4-dimethyl-3-nitro-phenyl)amine 
• 13438-26-1 2,6-dimethylbenzene-1,3-diamine 
• 632-92-8 2,4-dimethyl-1,3,5-trinitrobenzene 

Relevant academic research and scientific papers

Nitration of deactivated aromatic compounds via mechanochemical reaction

A variety of deactivated arenes were nitrated to their corresponding nitro derivatives in excellent yields under high-speed ball milling condition using Fe(NO3)3·9H2O/P2O5 as nitrating reagent. A radical involved mechanism was proposed for this facial, eco-friendly, safe, and effective nitration reaction.

PYRAZOLOPYRIMIDINE DERIVATIVES, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION FOR USE IN PREVENTING OR TREATING CANCER, AUTOIMMUNE DISEASE AND BRAIN DISEASE CONTAINING THE SAME AS AN ACTIVE INGREDIENT

The present invention relates to a pyrazolopyrimidine derivative, a preparation method thereof and a pharmaceutical composition comprising the same as an active ingredient for the prevention or treatment of cancer, autoimmune disease and brain disease. The pyrazolopyrimidine derivative of the present invention exhibits excellent Bruton's tyrosine kinase inhibition activity, so that it can be effectively used as a pharmaceutical composition for the prevention or treatment of cancer, autoimmune disease and Parkinson's disease.

Ethylammonium nitrate (EAN)/Tf2O and EAN/TFAA: Ionic liquid based systems for aromatic nitration

Acting as in situ sources of triflyl nitrate (TfONO2) and trifluoroacetyl nitrate (CF3COONO2), the EAN/Tf 2O and EAN/TFAA systems, generated via metathesis in the readily available ethylammonium nitrate (EAN) ionic liquid as solvent, are powerful electrophilic nitrating reagents for a wide variety of aromatic and heteroaromatic compounds. Comparative nitration experiments indicate that EAN/Tf2O is superior to EAN/TFAA for nitration of strongly deactivated systems. Both systems exhibit low substrate selectivity (K T/KB = 5-10) in (Figure presented) between values reported for covalent nitrates and preformed nitronium salts.

Overcoming regioselectivity issues inherent in bis-Troeger's base preparation

(Figure Presented) Bis-Troeger's base derivatives are a new family of molecular tweezers. A major drawback to their study is a lack of commercially available precursors, ortho-nitrocarboxylic acids. A reverse synthetic strategy starting from known dinitrodicarboxylic acids, which circumvents this problem, is presented. Via this methodology regioisomeric bis-TB derivatives can be prepared selectively, using only common aromatic amines that are typically commercially available.

2-IMIDAZOLINE, 2-OXAZOLINE, 2-THIAZOLINE, AND 4-IMIDAZOLE DERIVATIVES OF METHYLPHENYL, METHOXYPHENYL, AND AMINOPHENYL ALKYLSULFONAMIDES AND UREAS AND THEIR USE

The present invention concerns novel compounds represented by the Formula: STR1 wherein: A is R 1 q (R 3 R 60 N). sub.m (Z)(NR 2) n ; m and q are each 0 or 1, with the proviso that when q is 1, m is 0 and when q is 0, m is 1; Z is C=O or SO 2 ; n is 1 with the proviso that, when Z is C=O, m is 1; X is--NH--,--CH 2--, or--OCH 2--; Y is 2-imidazoline, 2-oxazoline, 2-thiazoline, or 4-imidazole; R 1 is H, lower alkyl, or phenyl, with the proviso that, when R 1 is H, m is 1; R 2, R 3, R 60 are each independently H, lower alkyl, or phenyl; R 4, R 5, R. sup.6, and R 7 are each independently hydrogen, lower alkyl,--CF. sub.3, lower alkoxy, halogen, phenyl, lower alkeny, hydroxyl, lower alkylsulfonamido, or lower cycloalkyl, wherein R. sup.2 and R 7 optionally may be taken together to form alkylene or alkenylene of 2 to 3 atoms in an unsubstituted or optionally substituted 5-or 6-membered ring, wherein the optional substituents on the ring are halo, lower alkyl, or--CN, with the proviso that, when R 7 is hydroxyl or lower alkylsulfonamido, then X is not--NH--when Y is 2-imidazoline. The compounds include pharmaceutically acceptable salts of the above. In the above formula A may be, for example, (R 1 SO 2 NR 2--), (R. sup.3 R 60 NSO 2 NR 2--), or (R 3 R 60 NCONR 2--). The invention also includes the use of the above compounds, and compositions containing them, as alpha 1A/1L agonists in the treatment of various disease states such as urinary incontinence, nasal congestion, priapism, depression, anxiety, dementia, senility, Alzheimer's, deficiencies in attentiveness and cognition, and eating disorders such as obesity, bulimia, and anorexia.

Thermal Stability Studies on a Homologous Series of Nitroarenes

The thermal stabilities of a number of nitroarenes were examined in solution and in condensed phase.In general, increasing the number of nitro groups decreased thermal stability.Changing the substituent on 1-X-2,4,6-trinitrobenzene from X = H to NH2 to CH3 to OH accelerated decomposition; this effect was attributed to increased ease of intramolecular proton transfer to an ortho nitro group, thus weakening the carbon-nitrogen bond.In solution, the effect of increasing substitution from n = 1 to n = 3 on Xn(NO2)3C6H3-n was uniformly that of decreasing the thermal stability of the species.However, in condensed phase, results suggested that crystal habit may be more important than molecular structure; for X = Br, CH3, and NH2, the more substituted species was the more stable.

Ozone-mediated Nitration of Alkylbenzenes and Related Compounds with Nitrogen Dioxide

In the presence of ozone, nitrogen dioxide exhibits a strong nitrating ability for alkylbenzenes at low temperatures, converting them into the corresponding nitro derivatives in high yield.The addition of a protonic acid as catalyst enhances considerably the ability of this nitrating system and leads to a good yield of polynitro compounds.The reaction is clean and proceeds rapidly without any accompanying side-chain substitution or aryl-aryl coupling.It shows no kinetic dependence on the concentration of substrates and, as far as can be judged from relative reactivities and isomer distributions of products, it gives the appearance of being an electrophilic aromatic process.A possible role for nitrogen trioxide has been suggested as the initial electrophilic agent for the nitration of alkylbenzenes.

Amidinoureas substituted in both the urea and amidino nitrogen positions

A method of inducing blood pressure reduction in humans and mammals by administering 2,6-disubstituted phenyl N-alkyl amidinoureas in which the phenyl ring is additionally substituted by a hydroxy, alkoxy, aralkoxy, alkenyloxy, alkynyloxy, acyloxy or halo acyloxy group and a novel class of amidinourea compounds having pharmaceutical uses, including blood pressure lowering activity.

Synthesis and Reactions of Some Pyridoquinolines (1,8-Diazaanthracenes)

The pyridoquinolines 1b, c, and e are synthesized for the first time directly by Friedlaender condensation from 4,6-diaminoisophthalic aldehyde (6) and ketones.Copper(I)-catalyzed decarboxylation of the 2,8-dicarboxylic acid 1e occurs in diethylene glycol monoethyl ether at temperatures as low as 165 deg C affording the parent compound 1a in high yield.Despite steric hindrance by a tert-butyl group methyllithium adds to position 2 of the 2,8-di-tert-butyl compound 1c producing the 1,2-dihydropyridoquinoline 9.Dehydrogenation of the octahydroquinoacridine 7 using palladium on carbon at 250 deg C yields the 1,2,3,4,7,12-hexahydro- (10) and the 5,14-dihydroquinoacridine (11).

Substituted phenyl amidinoureas

This invention relates to a method of lowering blood pressure in humans and mammals using 2,6-disubstituted phenyl amidinoureas in which the phenyl ring is additionally substituted by a hydroxy, alkoxy, aralkoxy, alkenyloxy, alkynyloxy, haloacyloxy, or acyloxy group and to novel 2,6-disubstituted phenyl amidinoureas which possess pharmaceutical properties, including blood pressure lowering activity.