603-02-1

Basic information

• Product Name: 2,4-dinitro-m-xylene
• Synonyms: m-Xylene, 2,4-dinitro-; 2,4-Dinitro-m-xylene; 3-05-00-00844 (Beilstein Handbook Reference); BRN 2333058; Benzene, 1,3-dimethyl-2,4-dinitro-; CCRIS 3124; 1,3-dimethyl-2,4-dinitrobenzene
• CAS NO: 603-02-1
• Molecular Formula: C₈H₈N₂O₄
• Molecular Weight: 196.1601
• EINECS: 210-029-2
• Mol File: 603-02-1.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 301.6°C at 760 mmHg
• Flash Point: 141.2°C
• Density: 1.346g/cm³
• Vapor Pressure: 0.00186mmHg at 25°C
• Refractive Index: 1.587
• CAS DataBase Reference: 2,4-dinitro-m-xylene(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-dinitro-m-xylene(603-02-1)
• EPA Substance Registry System: 2,4-dinitro-m-xylene(603-02-1)

Safety Data

• Hazardous Substances Data: 603-02-1(Hazardous Substances Data)

Usage

General Description

2,4-Dinitro-m-xylene is a chemical compound that belongs to the class of dinitroxylenes. It is a yellow crystalline solid at room temperature and is commonly used as an intermediate in the synthesis of various organic compounds such as dyes, pharmaceuticals, and pesticides. It is produced by the nitration of m-xylene, and it has two nitro groups attached to the benzene ring at positions 2 and 4. It is considered to be toxic and harmful if ingested, inhaled, or comes into contact with the skin, and thus, precautions must be taken when handling this substance. Additionally, it is important to dispose of 2,4-Dinitro-m-xylene properly to prevent environmental contamination and harm.

Upstream product

• 108-38-3 m-xylene 
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• 7664-93-9 sulfuric acid 
• 632-92-8 2,4-dimethyl-1,3,5-trinitrobenzene 
• 89-87-2 2,4-dimethylnitrobenzene 
• 81-20-9 2,6-dimethylnitrobenzene 
• 67083-28-7 2,6-dimethyl-3-nitroaniline 

Downstream Products

• 92149-68-3 (3-Nitro-2,4-xylyl)-(4-nitro-phenyl)-ether 
• 70261-49-3 2,4-dimethyl-3-nitrophenol 
• 94135-19-0 2,4-dimethyl-benzene-1,3,5-triyltriamine 
• 31167-04-1 (2,4-dimethyl-3-nitro-phenyl)amine 
• 13438-26-1 2,6-dimethylbenzene-1,3-diamine 
• 632-92-8 2,4-dimethyl-1,3,5-trinitrobenzene 

Relevant articles and documents

Nitration of deactivated aromatic compounds via mechanochemical reaction

A variety of deactivated arenes were nitrated to their corresponding nitro derivatives in excellent yields under high-speed ball milling condition using Fe(NO3)3·9H2O/P2O5 as nitrating reagent. A radical involved mechanism was proposed for this facial, eco-friendly, safe, and effective nitration reaction.

Ethylammonium nitrate (EAN)/Tf2O and EAN/TFAA: Ionic liquid based systems for aromatic nitration

Acting as in situ sources of triflyl nitrate (TfONO2) and trifluoroacetyl nitrate (CF3COONO2), the EAN/Tf 2O and EAN/TFAA systems, generated via metathesis in the readily available ethylammonium nitrate (EAN) ionic liquid as solvent, are powerful electrophilic nitrating reagents for a wide variety of aromatic and heteroaromatic compounds. Comparative nitration experiments indicate that EAN/Tf2O is superior to EAN/TFAA for nitration of strongly deactivated systems. Both systems exhibit low substrate selectivity (K T/KB = 5-10) in (Figure presented) between values reported for covalent nitrates and preformed nitronium salts.

2-IMIDAZOLINE, 2-OXAZOLINE, 2-THIAZOLINE, AND 4-IMIDAZOLE DERIVATIVES OF METHYLPHENYL, METHOXYPHENYL, AND AMINOPHENYL ALKYLSULFONAMIDES AND UREAS AND THEIR USE

The present invention concerns novel compounds represented by the Formula: STR1 wherein: A is R 1 q (R 3 R 60 N). sub.m (Z)(NR 2) n ; m and q are each 0 or 1, with the proviso that when q is 1, m is 0 and when q is 0, m is 1; Z is C=O or SO 2 ; n is 1 with the proviso that, when Z is C=O, m is 1; X is--NH--,--CH 2--, or--OCH 2--; Y is 2-imidazoline, 2-oxazoline, 2-thiazoline, or 4-imidazole; R 1 is H, lower alkyl, or phenyl, with the proviso that, when R 1 is H, m is 1; R 2, R 3, R 60 are each independently H, lower alkyl, or phenyl; R 4, R 5, R. sup.6, and R 7 are each independently hydrogen, lower alkyl,--CF. sub.3, lower alkoxy, halogen, phenyl, lower alkeny, hydroxyl, lower alkylsulfonamido, or lower cycloalkyl, wherein R. sup.2 and R 7 optionally may be taken together to form alkylene or alkenylene of 2 to 3 atoms in an unsubstituted or optionally substituted 5-or 6-membered ring, wherein the optional substituents on the ring are halo, lower alkyl, or--CN, with the proviso that, when R 7 is hydroxyl or lower alkylsulfonamido, then X is not--NH--when Y is 2-imidazoline. The compounds include pharmaceutically acceptable salts of the above. In the above formula A may be, for example, (R 1 SO 2 NR 2--), (R. sup.3 R 60 NSO 2 NR 2--), or (R 3 R 60 NCONR 2--). The invention also includes the use of the above compounds, and compositions containing them, as alpha 1A/1L agonists in the treatment of various disease states such as urinary incontinence, nasal congestion, priapism, depression, anxiety, dementia, senility, Alzheimer's, deficiencies in attentiveness and cognition, and eating disorders such as obesity, bulimia, and anorexia.