31181-89-2

Basic information

• Product Name: 5-CHLORO-2-FORMYLPYRIDINE
• Synonyms: 5-CHLORO-2-FORMYLPYRIDINE;5-Chloropyridine-2-carbaldehyde;5-Chloro-2-pyridinecarbaldehyde;5-Chloropyridine-2-carboxaldehyde;5-Chloro-2-pyridinecarboxaldehyde;Picolinaldehyde,5-chloro- (8CI);2-Pyridinecarboxaldehyde, 5-chloro-;5-Chloro-2-formylpyridine, 5-Chloropicolinaldehyde
• CAS NO: 31181-89-2
• Molecular Formula: C₆H₄ClNO
• Molecular Weight: 141.56
• EINECS: 1312995-182-4
• Product Categories: Pyridine;Boronic Acid;Building Blocks;Heterocycle-Pyridine series
• Mol File: 31181-89-2.mol
• Article Data: 4

Chemical Properties

• Melting Point: 66-68°
• Boiling Point: 208℃
• Flash Point: 79℃
• Appearance: /
• Density: 1.332
• Vapor Pressure: 0.22mmHg at 25°C
• Refractive Index: 1.593
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility: soluble in Methanol
• PKA: 1.44±0.10(Predicted)
• CAS DataBase Reference: 5-CHLORO-2-FORMYLPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-CHLORO-2-FORMYLPYRIDINE(31181-89-2)
• EPA Substance Registry System: 5-CHLORO-2-FORMYLPYRIDINE(31181-89-2)

Safety Data

• Hazard Codes: Xi
• Statements: 36-43
• Safety Statements: 26-36/37
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 31181-89-2(Hazardous Substances Data)

Usage

General Description

5-CHLORO-2-FORMYLPYRIDINE is a chemical compound with the molecular formula C6H4ClNO, consisting of a pyridine ring with a chlorine atom at the fifth position and a formyl group at the second position. It is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals due to its versatile reactivity. This chemical has also been studied for its potential anti-inflammatory and anti-cancer properties. 5-CHLORO-2-FORMYLPYRIDINE is known to be a flammable liquid and should be handled with care due to its hazardous nature.

InChI:InChI=1/C6H4ClNO/c7-5-1-2-6(4-9)8-3-5/h1-4H

Upstream product

• 68-12-2 N,N-dimethyl-formamide 
• 244221-57-6 5-chloro-2-iodo-pyridine 
• 72093-07-3 2-methyl-5-chloropyridine 

Downstream Products

• 1190747-05-7 C₃₀H₃₄ClN₇O 
• 923949-15-9 (4S)-4-benzyl-3-[(2E)-3-(5-chloropyridin-2-yl)prop-2-enoyl]-1,3-oxazolidin-2-one 
• 89809-64-3 2-cyano-5-chloropyridine 

Relevant articles and documents

Synthesis of new Zn (II) complexes for photo decomposition of organic dye pollutants, industrial wastewater and photo-oxidation of methyl arenes under visible-light

Synthesis of new Schiff's base Zn-complexes for photo-oxidation of methyl arenes and xylenes are reported under visible light irradiation conditions. All the synthesized new ligands and Zn-complexes are thoroughly characterized with various spectral analyses and confirmed as 1:1 ratio of Zn and ligand with distorted octahedral structure. The bandgap energies of the ligands are higher than its Zn-complexes. These synthesized new Zn(II) complexes are used for the photo-fragmentation of organic dye pollutants, photodegradation of food industrial wastewater and oxidation of methyl arenes which are converted into its respective aldehydes with moderate yields under visible light irradiation. The photooxidation reaction dependency on the intensity of the visible light was also studied. With the increase in the dosage of photocatalyst, the methyl groups are oxidized to get aldehydes and mono acid products, which are also identified from LC-MS data. Finally, [Zn(PPMHT)Cl] is with better efficiency than [Zn(PTHMT)Cl] and [Zn(MIMHPT)Cl] for oxidation of methyl arenes is reported under visible-light-driven conditions.

PIPERIDINOYL-PYRROLIDINE AND PIPERIDINOYL-PIPERIDINE COMPOUNDS

The present invention relates to a class of compounds of general formula (I) and the salts, hydrates, solvates, polymorphs and prodrugs wherein n, R6, R7 and R10 are as defined herein and especially to MCR4 agonist compounds of formula (I), to their use in medicine, particularly in the treatment of sexual dysfunction and obesity, to intermediates useful in their synthesis and to compositions containing them.