72093-07-3

Basic information

• Product Name: 5-CHLORO-2-PICOLINE
• Synonyms: 5-CHLORO-2-PICOLINE;5-CHLORO-2-METHYLPYRIDINE;3-Chloro-6-methylpyridine;5-CHLORO-2-METHYLPYRIDINE (5-CHLORO-2-PICOLINE);5-CHLORO-2-PICOLINE5-CHLORO-2-METHYLPYRIDINE;5-Chloro-3-methylpyridine;2-Methyl-5-chloropyridine;Pyridine, 5-chloro-2-methyl-
• CAS NO: 72093-07-3
• Molecular Formula: C₆H₆ClN
• Molecular Weight: 127.57
• Product Categories: Pyridine;Pyridines;pyridine series
• Mol File: 72093-07-3.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 163 °C at 760 mmHg
• Flash Point: 62 °C
• Appearance: /
• Density: 1.15g/cm³
• Vapor Pressure: 2.76mmHg at 25°C
• Refractive Index: 1.526
• Storage Temp.: Room temperature.
• PKA: 3.67±0.10(Predicted)
• CAS DataBase Reference: 5-CHLORO-2-PICOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-CHLORO-2-PICOLINE(72093-07-3)
• EPA Substance Registry System: 5-CHLORO-2-PICOLINE(72093-07-3)

Safety Data

• Hazardous Substances Data: 72093-07-3(Hazardous Substances Data)

Usage

General Description

5-Chloro-2-picoline is a chemical compound with the molecular formula C6H4ClN. It is classified as a chlorinated heterocyclic aromatic compound and is commonly used as an intermediate in the production of pharmaceuticals, agrochemicals, and other organic compounds. 5-Chloro-2-picoline is a colorless to pale yellow liquid with a sharp, pungent odor. It is primarily used in the synthesis of pyridine derivatives and is an important building block for the production of a wide variety of chemicals. 5-CHLORO-2-PICOLINE is also used as a solvent in various industrial processes and as a reagent in organic synthesis. Additionally, 5-Chloro-2-picoline has applications in the manufacturing of herbicides, pesticides, and other agricultural chemicals. Its properties and versatility make it a valuable and widely utilized chemical compound in various industries.

InChI:InChI=1/C6H6ClN/c1-5-2-3-6(7)4-8-5/h2-4H,1H3

Upstream product

• 1480-65-5 2-fluoro-5-chloropyridine 
• 1116-98-9 cyanoacetic acid tert-butyl ester 

Downstream Products

• 52313-58-3 5-chloro-2-methylpyridine-N-oxide 
• 1060814-82-5 ethyl 2-(5-chloropyridin-2-yl)acetate 
• 31181-89-2 5-chloro-2-pyridine carboxaldehyde 
• 63523-74-0 (6-methyl-pyridin-3-yl)-phenyl-amine 
• 605680-98-6 2(S)-azido-4-(5-chloro-2-pyridyl)-3(S)-phenylbutane 
• 605681-00-3 3-(3-bromophenyl)-4-(5-chloro-2-pyridyl)-2-butanone 
• 605681-02-5 3-(3-bromophenyl)-4-(5-chloro-2-pyridyl)-2-butanol 
• 3256-88-0 5-phenyl-2-picoline 
• 104395-86-0 1-(5-methyl-pyridin-2-yl)piperazine 
• 907208-89-3 1-(tert-butyloxycarbonyl)-4-(5-methylpyridin-2-yl)piperazine 
• 605680-97-5 4-(5-chloro-2-pyridyl)-3(S)-phenyl-2(R)-butanol 
• 38956-79-5 3-hydrazinyl-6-methylpyridazine 
• 605681-01-4 2-(bromomethyl)-5-chloropyridine 
• 132308-19-1 methyl 5-chloropyridine-2-carboxylate 

Relevant articles and documents

Development of Two Synthetic Approaches to an APJ Receptor Agonist Containing a Tetra- ortho-Substituted Biaryl Pyridone

The development and implementation of two process syntheses to provide BMS-986224, an agonist of the APJ receptor, are reported. The first-generation synthesis of BMS-986224 relied on a key enamine cyclization to construct the pyridone core; however, the overall efficiency of this route was limited by the linear synthesis of the hindered biaryl pyridone. This lack of convergence is solved in a second-generation route that minimizes low-temperature lithiation chemistry, replaces costly Pd coupling with scalable nucleophilic arylation, and reduces step count. The improved synthesis was enabled by a new Negishi coupling method that addresses limitations of the Suzuki-Miyaura literature for tetra-ortho-substituted biaryl pyridones.