31184-53-9

Basic information

• Product Name: 1,2,4,5-tetrahydro-7H-benzo[g]indazol-7-one
• CAS NO: 31184-53-9
• Molecular Formula: C₁₁H₁₀N₂O
• Molecular Weight: 186.2099
• Mol File: 31184-53-9.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 364.5°C at 760 mmHg
• Flash Point: 165.4°C
• Density: 1.33g/cm³
• Vapor Pressure: 1.67E-05mmHg at 25°C
• Refractive Index: 1.685
• CAS DataBase Reference: 1,2,4,5-tetrahydro-7H-benzo[g]indazol-7-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2,4,5-tetrahydro-7H-benzo[g]indazol-7-one(31184-53-9)
• EPA Substance Registry System: 1,2,4,5-tetrahydro-7H-benzo[g]indazol-7-one(31184-53-9)

Safety Data

• Hazardous Substances Data: 31184-53-9(Hazardous Substances Data)

Usage

Chemical class

Belongs to the benzo[g]indazole class of organic compounds.

Structure

Heterocyclic compound with a bicyclic structure consisting of a benzene ring fused to a five-membered nitrogen-containing ring.

Potential applications

Medicinal chemistry, specifically in the development of pharmaceutical drugs.

Biological activity

May exhibit biological activity and has been studied for its potential therapeutic effects.

Future research

Specific properties and potential uses may be further investigated in future research.

Upstream product

• 1078-19-9 6-methoxy-3,4-dihydro-1(2H)-naphthalenone 
• 68950-67-4 6-methoxy-1-oxo-1,2,3,4-tetrahydronaphthalene-2-carbaldehyde 
• 501936-07-8 7-methoxy-4,5-dihydro-2H-benzo[g]indazole 
• 851486-82-3 2-(hydroxymethylene)-6-methoxy-1-tetralone 
• 14707-26-7 4,5-Dihydro-7-methoxy-1H-benzindazol 

Relevant articles and documents

Synthesis of aryl-substituted or aryl-fused N-hydroxyethyl and N-hydroxymethypyrazole derivatives as potential ligands for the estrogen receptor

A new series of N-hydroxyethylpyrazole (12a-f) and N-hydroxymethylpyrazole derivatives (15a-f) were designed for their estrogenic activities, having a 11.0 ± 0.5 A distance between their two hydroxyl groups, aliphatic-OH and phenolic-OH similar to 17β-estradiol (E2) as an endogenous hormone. To synthesize the title compounds, the key intermediate 1,3-dicarbonyl derivatives (2 and 8), were treated with hydrazine hydrate to produce the pyrazole ring 5 and 9. Further hydroxyalkylation of the latter produced the title pyrazoles. The position of hydroxyethyl or hydroxymethyl substituents in the products was determined through 2D NOE NMR spectroscopy.

Azasteroids compounds and derivatives

Azasteroids and certain derivatives each of a five ring system containing at least one aromatic nucleus and at least one nitrogen atom. The ring system is fused to a tetrahydrotetralin system or a tetrahydrophenanthrene system. The compounds have solubility in water and disclose antimicrobial, antifertility and potentiate the activity of antibiotics and certain anticancer agents.