31184-53-9

Usage

Chemical class

Belongs to the benzo[g]indazole class of organic compounds.

Structure

Heterocyclic compound with a bicyclic structure consisting of a benzene ring fused to a five-membered nitrogen-containing ring.

Potential applications

Medicinal chemistry, specifically in the development of pharmaceutical drugs.

Biological activity

May exhibit biological activity and has been studied for its potential therapeutic effects.

Future research

Specific properties and potential uses may be further investigated in future research.

Upstream product

• 68950-67-4 6-methoxy-1-oxo-1,2,3,4-tetrahydronaphthalene-2-carbaldehyde 
• 1078-19-9 6-methoxy-3,4-dihydro-1(2H)-naphthalenone 
• 501936-07-8 7-methoxy-4,5-dihydro-2H-benzo[g]indazole 
• 851486-82-3 2-(hydroxymethylene)-6-methoxy-1-tetralone 
• 14707-26-7 4,5-Dihydro-7-methoxy-1H-benzindazol 

Relevant academic research and scientific papers

Synthesis of aryl-substituted or aryl-fused N-hydroxyethyl and N-hydroxymethypyrazole derivatives as potential ligands for the estrogen receptor

A new series of N-hydroxyethylpyrazole (12a-f) and N-hydroxymethylpyrazole derivatives (15a-f) were designed for their estrogenic activities, having a 11.0 ± 0.5 A distance between their two hydroxyl groups, aliphatic-OH and phenolic-OH similar to 17β-estradiol (E2) as an endogenous hormone. To synthesize the title compounds, the key intermediate 1,3-dicarbonyl derivatives (2 and 8), were treated with hydrazine hydrate to produce the pyrazole ring 5 and 9. Further hydroxyalkylation of the latter produced the title pyrazoles. The position of hydroxyethyl or hydroxymethyl substituents in the products was determined through 2D NOE NMR spectroscopy.

Synthesis and Study of the Potential Antiallergic Activity of Some Pyrazole Derivatives

The synthesis and study of the oral antiallergic activity of a series of monopyrazole derivatives (2-14) considered as analogues of active bispyrazole 1 are described.None of the compounds showed significant inhibition of the rat passive cutaneous anaphylaxis (PCA), with the exception of the already known 5-aminoindazole (2).The activity of this compound is, however, lower than that of compound 1.

Azasteroids compounds and derivatives

Azasteroids and certain derivatives each of a five ring system containing at least one aromatic nucleus and at least one nitrogen atom. The ring system is fused to a tetrahydrotetralin system or a tetrahydrophenanthrene system. The compounds have solubility in water and disclose antimicrobial, antifertility and potentiate the activity of antibiotics and certain anticancer agents.