31189-07-8

Usage

Uses

Used in Medicinal Chemistry:
2,3-Dihydro-6,7-dimethoxy-4H-1-benzothiopyran-4-on is used as a starting material for the synthesis of biologically active compounds, leveraging its unique structural features to contribute to the development of new pharmaceuticals.
Used in Pharmaceutical Development:
2,3-Dihydro-6,7-dimethoxy-4H-1-benzothiopyran-4-on is utilized in the development of pharmaceuticals due to its potential to be incorporated into the structures of drugs with therapeutic applications, capitalizing on its heterocyclic and dimethoxy-substituted nature.
Used in Agrochemical Development:
2,3-Dihydro-6,7-dimethoxy-4H-1-benzothiopyran-4-on also has potential applications in the agrochemical industry, where it may be used in the creation of compounds for pest control or other agricultural purposes, taking advantage of its chemical properties and structural attributes.

Upstream product

• 700-96-9 3,4-dimethoxythiophenol 
• 23095-31-0 3,4-dimethoxybenzene-1-sulfonyl chloride 
• 91-16-7 1,2-dimethoxybenzene 
• 60169-56-4 3-(3,4-dimethoxyphenylthio)propanoic acid 
• 62208-40-6 6,7-dimethoxy-thiochroman-2-one 

Relevant academic research and scientific papers

Reaction of β-ethylsulfanylpropionyl tetrafluoroborate with halogen- containing aromatic and heteroaromatic compounds

Acylation of halogen-containing electron-rich aromatic and heteroaromatic compounds with β-ethylsulfanylpropionyl tetrafluoroborate leads to the formation of 6-membered sulfonium salts fused with aromatic or heteroaromatic rings. Base induced cleavage of

Novel inhibitors of AChE and Aβ aggregation with neuroprotective properties as lead compounds for the treatment of Alzheimer's disease

A series of sulfone analogs of donepezil were designed and synthesized as novel acetylcholinesterase (AChE) inhibitors with the potent inhibiting Aβ aggregation and providing neuroprotective effects as potential modalities for Alzheimer's disease (AD). Most of the target compounds displayed effective inhibition of AChE, especially compound 24r which displayed powerful inhibitory activity (IC50 = 2.4 nM). Kinetic and docking studies indicated that compound 24r was a mixed-type inhibitor. Furthermore, in glyceraldehyde (GA)-exposed SH-SY5Y differentiated neuronal cells, compound 24r could potently inhibit AChE, reduce tau phosphorylation at S396 residue, provide neuroprotection by rescuing neuronal morphology and increasing cell viability. It was also found to reduce amyloid aggregation in the presence of AChE. In addition, compound 24r showed evident protections from mitochondrial membrane dysfunction and oxidative stress in okadaic acid-induced pharmacological models. Moreover, compound 24r exhibited more effective treatment prospects in vivo than donepezil, including a moderate blood-brain barrier permeability, a more potent AChE inhibitory activity and behavioral improvement in scopolamine-induced cognition-impaired mice model at a much lower dose. Collectively, compound 24r is a promising lead compound for further investigation to discovery and development of new anti-AD agents.

Benzopyranopyrazolyl derivatives for the treatment of inflammation

A class of benzopyranopyrazolyl derivatives is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula I STR1 wherein A is --(CH2)m --X--(CH2)n --; wherein X is S(O)p or O; wherein m is 0 or 1; wherein n is 0 or 1; wherein p is 0 or 1; wherein B is selected from phenyl and five and six membered heteroaryl; wherein R1 is selected from lower haloalkyl, cyano, formyl, lower alkoxycarbonyl, lower alkoxy, lower N-alkylaminocarbonyl, N-phenylaminocarbonyl, lower N,N-dialkylaminocarbonyl and lower N-alkyl-N-phenylaminocarbonyl; wherein R2 is phenyl substituted at a substitutable position with a radical selected from lower alkylsulfonyl and sulfamyl; and wherein R4 is one or more radicals selected from hydrido, halo, lower alkylthio, lower alkylsulfinyl, lower alkyl, cyano, carboxyl, lower alkoxycarbonyl, aminocarbonyl, lower haloalkyl, hydroxyl, lower alkoxy, amino, lower N-alkylamino, lower N,N-dialkylamino, lower hydroxyalkyl and lower haloalkoxy; or a pharmaceutically-acceptable salt thereof.